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Studies on the relationship between the plasma concentration of proteins synthesized in the liver and liver cell function measured by ICG

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Summary

The plasma levels of nine liver-made proteins were compared with functioning liver cell mass estimated by an index, ICG capacity, in 98 patients with liver diseases. ICG capacity was parallel to the functioning liver cell mass estimated by the severelity, acuteness, type and nature of the disease. Plasma levels of prealbumin, haptoglobin and α1 acid glycoprotein were in proportion to the change in ICG capacity in acute and chronic liver cell injuries. Plasma levels of albumin and transferrin were parallel to ICG capacity only in chronic liver cell injuries. Plasma levels of α1 antitripsin were high in the active stage of liver diseases and were pallalel to ICG capacity only in inactive stage. Plasma levels of ceruloplasmin, α2 macro globulin and β{1}C/β1A globulin were not parallel to ICG capacity in any stage or state of liver disease. It was concluded that synthetic rates and plasma half times of the former 5 liver made proteins are the main factors for the determinations of their plasma levels in liver diseases.

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Authors and Affiliations

  1. Assistants in the 2nd Department of Medicine, Toho University, School of Medicine, Japan

    Makoto Inaba, Toshiyuki Takane, Hiromi Yoshida, Ikuya Sakumoto, Hiroo Hosaka & Kozo Mizuiri

  2. School of Medicine, Toho University, Japan

    Tohru Abei (Associate Professor of Medicine)

Authors
  1. Makoto Inaba
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  2. Toshiyuki Takane
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  3. Hiromi Yoshida
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  4. Ikuya Sakumoto
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  5. Hiroo Hosaka
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  6. Kozo Mizuiri
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  7. Tohru Abei
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Inaba, M., Takane, T., Yoshida, H. et al. Studies on the relationship between the plasma concentration of proteins synthesized in the liver and liver cell function measured by ICG. Gastroenterol Jpn 9, 261–276 (1974). https://doi.org/10.1007/BF02774792

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  • DOI: https://doi.org/10.1007/BF02774792

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