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The effect of motilin on the gastrointestinal propulsion in rats

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Summary

We studied the gastrointestinal propulsion in unanaesthetized rats by51Cr method that permits the simultaneous determination of two functions of the gastric emptying and the intestinal propulsion. The results obtained are as follows:

  1. 1)

    The semi-logarithmic presentation of the gastric emptying showed a linear relationship with the time.

  2. 2)

    When synthetic motilin was subcutaneously injected at the dose of 1µg/kg, the gastric emptying was promoted to a statistically significant extent.

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Authors and Affiliations

  1. The 2nd Department of Internal Medicine, Nagoya University School of Medicine, Tsuruma-cho, Showa-ku, 466, Nagoya, Japan

    Saburo Nakazawa M.D., Kosei Segawa M.D., Hitoshi Hidano M.D., Yoshihisa Tsukamoto M.D., Masafumi Aichi M.D. & Tomohiro Ichikawa M.D.

Authors
  1. Saburo Nakazawa M.D.
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  2. Kosei Segawa M.D.
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  3. Hitoshi Hidano M.D.
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  4. Yoshihisa Tsukamoto M.D.
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  5. Masafumi Aichi M.D.
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  6. Tomohiro Ichikawa M.D.
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Nakazawa, S., Segawa, K., Hidano, H. et al. The effect of motilin on the gastrointestinal propulsion in rats. Gastroenterol Jpn 13, 50–53 (1978). https://doi.org/10.1007/BF02774154

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  • DOI: https://doi.org/10.1007/BF02774154

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