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Correction of biotransformation of xenobiotics by α-tocopherol in combination with nicotinamide and methionine in the liver damaged by ultrasound

  • Pharmacology And Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Six day after rat liver sonication, the content of cytochrome P-450, rate of NADPH oxidation, activity of NADPH—cytochrome P-450 reductase, and rate of aniline hydroxylation in the microsomal fraction decrease. After 12 days, the rate of ethylmorphine N-demethylation also decreases. Intragastral administration of methionine, nicotinamide, and vitamin E for 6 and 12 days activates these enzymes and uridine 5′-diphosphate glucuronyl transferase.

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Authors and Affiliations

  1. Laboratory of Biochemical Pharmacology, Institute of Biochemistry, Byelorussian Academy of Sciences, USSR

    I. V. Zverinskii, M. I. Bushma, L. F. Legon’kova, P. I. Lukienko & K. A. Eismont

  2. Department of Pathological Physiology, Medical Institute, Grodno

    I. V. Zverinskii, M. I. Bushma, L. F. Legon’kova, P. I. Lukienko & K. A. Eismont

Authors
  1. I. V. Zverinskii
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  2. M. I. Bushma
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  3. L. F. Legon’kova
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  4. P. I. Lukienko
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  5. K. A. Eismont
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Additional information

Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 123, No. 4, pp. 420–423, April, 1997

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Zverinskii, I.V., Bushma, M.I., Legon’kova, L.F. et al. Correction of biotransformation of xenobiotics by α-tocopherol in combination with nicotinamide and methionine in the liver damaged by ultrasound. Bull Exp Biol Med 123, 362–365 (1997). https://doi.org/10.1007/BF02766188

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  • DOI: https://doi.org/10.1007/BF02766188

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