Abstract
Eight subjects with asthma were given, orally, increasing doses of W10294A (100, 200, 300 and 400 mg), 300 mg aminophylline and placebo on separate days. Forced expiratory flow rates were measured at hourly intervals for 6 h. Significant increases in mean forced expiratory volume in one second (FEV1) were recorded with the 300 and 400 mg W10294A and 300 mg aminophylline doses compared to placebo. The peak effect of W10294A was recorded at 3 h. The 400 mg W10294A dose resulted in mean FEV1 increases similar to those recorded after the 300 mg aminophylline dose. The mean FEV1 was significantly improved for 6 h by the W10294A. Small but significant increases in mean pulse rate were seen with all doses of W10294A and 300 mg of aminophylline when compared to placebo. Mild headaches or drowsiness were reported by 6 of the 8 subjects after being given W10294A. No headache or drowsiness was reported after 300 mg aminophylline or placebo. We conclude that W10294A causes a dose-related improvement in forced expiratory flow rates and is an effective long-acting bronchodilator with tolerable side-effects when given in single oral doses to asthmatic subjects.
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Supported by a grant from Warner Lambert Research Institute, Morris Plains, New Jersey.
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Littner, M.R. W10294A: A new bronchodilator. Lung 154, 187–194 (1976). https://doi.org/10.1007/BF02713533
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DOI: https://doi.org/10.1007/BF02713533