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Immunotoxic effects during acute ethylene glycol poisoning

  • Pharmacology and Toxicology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Experiments on outbred and inbred male CBA mice showed that acute poisoning with ethylene glycol (0.8 LD50) increased mortality from infections, decreased the number of spleen colony-forming units, inhibited antibody formation (mainly to thymus-dependent antigens, and suppressed natural and antibody-dependent cytotoxicity and delayed-type hypersensitivity. Ethylene glycol in concentrations of 10 and 100 mMin vitro inhibited the formation of antibody-producing cells by acting on T and B lymphocytes.

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Authors and Affiliations

  1. Department of Toxicology, Saratov Medical University, Saratov, USSR

    P. F. Zabrodskii & V. G. Germanchuk

Authors
  1. P. F. Zabrodskii
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  2. V. G. Germanchuk
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 10, pp. 415–417, October, 2000

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Zabrodskii, P.F., Germanchuk, V.G. Immunotoxic effects during acute ethylene glycol poisoning. Bull Exp Biol Med 130, 967–968 (2000). https://doi.org/10.1007/BF02682040

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  • DOI: https://doi.org/10.1007/BF02682040

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