Methods of extracting polyprenols from Alcea nudiflora and their immunotropic actions were studied. Administration of Alcea nudiflora polyprenols to mice simultaneously with immunization with sheep erythrocytes produced marked stimulation of primary antibody formation, apparent as an increase in the number of antibody-forming cells in the spleen. In addition, there were increases in the cellularity of the central and peripheral organs of immunity, along with increases in blood erythrocyte and leukocyte levels. The immunomodulatory action of Alcea nudiflora polyprenols was seen not only in normal animals, but also in animals with secondary immunodeficiency states developing in acute toxic hepatitis and sublethal irradiation. In terms of activity in these experiments, Alcea nudiflora polyprenols were as active as the known immunostimulatory substance Immunal.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 50, No. 1, pp. 24 – 27, January, 2016.
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Syrov, V.N., Vais, E.V., Khidyrova, N.K. et al. Results of Experimental Studies of the Immunotropic Action of Polyprenols Extracted from Alcea Nudiflora . Pharm Chem J 50, 29–32 (2016). https://doi.org/10.1007/s11094-016-1393-2
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DOI: https://doi.org/10.1007/s11094-016-1393-2