Summary
Purified bovine cathepsin B, when incubated with isolated rat islets of Langerhans, completely converts proinsulin to insulin as demonstrated by the incorporation of14C-leucine into islet proteins, releasing lysine as the only basic amino acid. Cathepsin B antibodies raised in rabbit inhibited the above conversion.
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CDRI Communication No. 2703
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Bansal, R., Ahmad, N. & Kidwai, J.R. In vitro conversion of proinsulin to insulin by cathepsin B in isolated islets and its inhibition by cathepsin B antibodies. Acta diabet. lat 17, 255–266 (1980). https://doi.org/10.1007/BF02581326
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DOI: https://doi.org/10.1007/BF02581326