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Quantitative electron-microscopic studies of langerhans islets in normoglycemic chinese hamsters of a diabetic strain

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Summary

On the basis of previous studies of the retina and the pituitary, normoglycemic Chinese hamsters from a diabetic strain were divided into two groups, depending on the thickness of their capillary basement membrane and on the number of somatotrophs. Both values were significantly lower in group I than in group II. Quantitative electron microscopy of the islets of Langerhans showed in group II a tendency to a volume increase for A2-cells, to a decrease for D- and B-cells. Also the number of B-granules and the surface area of electron dense material deposited in B-cells appeared to be increased in group II. Hypotheses are offered to explain the islet changes in correlation to previous findings in the retina and pituitary.

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Authors and Affiliations

  1. Institut für Tierpathologie, Universität Bern, Postfach 2735, Bern, Switzerland

    Veronika Meister & Giovanni L. Rossi

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  1. Veronika Meister
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  2. Giovanni L. Rossi
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This paper is dedicated to Prof. Dr. Chr. Hedinger on occasion of his 60th birthday.

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Meister, V., Rossi, G.L. Quantitative electron-microscopic studies of langerhans islets in normoglycemic chinese hamsters of a diabetic strain. Acta diabet. lat 15, 72–80 (1978). https://doi.org/10.1007/BF02581009

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  • DOI: https://doi.org/10.1007/BF02581009

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