Summary
Among the different factors which could be responsible for the retinal vascular disturbances in diabetic retinopathy, we have investigated platelet populations, sialic acid content of platelets and collagen-induced platelet aggregation. The following results were obtained: a) there was no modification of platelet population distribution except for population A; b) there was a modification of collagen-induced platelet aggregation; the lag time was increased in diabetics.
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References
Aminoff D.: Methods for the Quantitative Estimation of N-acetylneuraminic Acid and their Applications to Hydrolysates of Sialo Mucoids - Biochem. J.81, 384, 1961.
Ashton N.: Studies on the Retinal Capillaries in Relation to Diabetic and Other Retinopathies - Brit. J. Ophthal.47, 521, 1963.
Bloodworth J.M.B. Jr.: Fine Structure of Retina in Human and Canine Diabetes Mellitus - In:Kimura S. J., Caygill W. M. (Eds): Vascular Complications of Diabetes Mellitus with Special Emphasis on Microangiopathy of the Eye. C. V. Mosby Co., St. Louis/Mo., 1967; p. 73.
Born G. V.: Aggregation of Blood Platelets by Adenosine Diphosphate and its Reversal - Nature (Lond.)194, 927, 1962.
Caen J. P., Legrand Y.: Abnormalities in the Platelet Collagen Reaction- Ann. N. Y. Acad. Sci.201, 194, 1972.
Chesney C. M., Harper E., Colman R. W.: Critical Role of the Carbohydrate Side Drains of Collagen in Platelet Aggregation - J. clin. Invest.51, 2693, 1972.
Chmielewski J., Farbiszewski R.: Platelet Factor 4 Release during Human Platelet Aggregation in Diabetic Patients - Thromb. Diathes. haemorrh. (Stuttg.)24, 203, 1970.
Hassanein A. A., Elgraf T. A., El Baz Z.: Platelet Aggregation in Diabetes Mellitus and the Effect of Insulinin vivo on Aggregation - Thromb. Diathes. haemorrh. (Stuttg.)27, 114, 1971.
Heath H.: Platelet Adhesiveness and Aggregation in Relation to Diabetic Retinopathy- Diabetologia5, 308, 1971.
Hellem A. J.: Adenosinediphosphate Induced Platelet Adhesiveness in Diabetes Mellitus with Complications - Acta med. scand.190, 291, 1971.
Kang A. H., Piez K. A., Gross J.: Characterization of the Cyanogen Bromide Peptides from the α1 Chain of Chick Skin Collagen - Biochemistry (Wash.)8, 1506, 1969.
Katzman R. L., Kang A. H., Beachey E. H.: Collagen-Induced Platelet Aggregation: Involvement of an Active Glycopeptide Fragment (α1 CB5) - Science181, 670, 1973.
Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J.: Protein Measurement with the Folin Phenol Reagent - J. biol. Chem.193, 265, 1951.
Mester L., Szabados L.: Effect of Sialyltransferases and Sialydoses on the Function of the Platelet Membrane - 9th Int. Congr. Biochemistry, Stockholm 1973; p. 275.
Mester L., Szabados L., Guinebault P. R., Caen J., Levy-Toledano S.: Variations de l’acide sialique plaquettaire dans les thrombopathies constitutionnelles et acquises - C. R. Acad. Sci. (Paris)273, 2157, 1971.
Mustard J. F., Murphy E. A., Rowsell H. C., Downie H. G.: Factors Influencing Thrombus Formationin vivo - Amer. J. Med.33, 621, 1962.
Niewiazowski S., Lipinski B., Farbiszewski R., Poplawski A.: The Release of Platelet F4 during Platelet Aggregation and the Possible Significance of this Reaction in Haemostasis - Experientia (Basel)24, 343, 1968.
Nilsson I. M.: Changes in the Coagulation and Fibrinolytic Systems Predisposing to Thrombosis - Acta med. scand.387 (Suppl.), 15, 1967.
Nordöy A., Rödset J.M.: Platelet Phospholipids and their Function in Patients with Juvenile Diabetes and Maturity Onset Diabetes - Diabetes19, 698, 1970.
Ödegaard A. E., Skålhegg B. A., Hellem A. J.: ADP-Induced Platelet Adhesiveness as a Diagnostic Test in von Willebrand’s Disease - Thromb. Diathes. haemorrh. (Stuttg.)11, 23, 1964.
Regnault F.: Rôle des plaquettes dans la pathogénie de la rétinopathie diabétique - Sem. Hôp. (Paris)48, 893, 1972).
Regnault F., Bonsch M., Pasticier M., Kern P., Romquin N.: Adhésivité et agrégation plaquettaire au cours de la rétinopathie diabétique - Bull. Soc. franç. Ophtal.85, 221, 1972.
Regnault F., Duhault J., Schaub C., Brégeat P.: Aspects généraux de la rétinopathie diabétique - Acta diabet. lat. 1975. (Unpublished data).
Regnault F., Kern P.: Modifications de l’agrégation plaquettaire chez les diabétiques atteints de rétinopathie - C. R. Soc. Biol. (Paris)165, 769, 1971.
Renaud S.: Diet, Drugs and Thrombosis - Canad. med. Ass. J.108, 458, 1973.
Sweeney E. A., Gershoff J. N., Antoniades H. N.: Observations onin vitro andin vivo Agglutination of Platelets by ‘Bound’ Insulin Concentrates- Proc. Soc. exp. Biol. (N. Y.)121, 880, 1966.
Vainer H., Lukasiewicz H., Jeaneau Ch.: L’hétérogénéité des plaquettes humaines: propriétés biochimiques et physiologiques des populations plaquettaires humaines - Journées angiologiques de langue française, 17–19 mars 1971. Flammarion Éd., Paris, 1971.
Warren L.: Thiobarbituric Acid Assay of Sialic Acid - J. biol. Chem.234, 1971, 1959.
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Roux, E., Romquin, N., Laurent, M. et al. Modification of human platelet behaviour in diabetes. Acta diabet. lat 14, 185–191 (1977). https://doi.org/10.1007/BF02580966
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DOI: https://doi.org/10.1007/BF02580966