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Defects of Platelet Granules and Secretion

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Platelets in Thrombotic and Non-Thrombotic Disorders

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Abstract

Inherited platelet disorders are usually classified according to the defect in the platelets. These comprise defects of platelet receptors, signal transduction, cytoskeleton, and platelet granule secretion. Platelet α-granules, δ-granules, or both may be affected resulting in phenotypical changes. According to the disorder platelet size and morphology can also be altered.

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Authors and Affiliations

  1. Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany

    Barbara Zieger

Authors
  1. Barbara Zieger
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Correspondence to Barbara Zieger .

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Editors and Affiliations

  1. Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia , Perugia, Italy

    Paolo Gresele

  2. Houston Methodist Hospital , Houston, Texas, USA

    Neal S. Kleiman

  3. Bloodworks Northwest, University of Washington , Seattle, Washington, USA

    José A. Lopez

  4. Sackler Inst of Pulmonary Pharmacol, King’s College London, London, United Kingdom

    Clive P. Page

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Zieger, B. (2017). Defects of Platelet Granules and Secretion. In: Gresele, P., Kleiman, N., Lopez, J., Page, C. (eds) Platelets in Thrombotic and Non-Thrombotic Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-47462-5_61

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