Skip to main content
SpringerLink
Log in

Fibrinolytic therapy for deep vein thrombosis and pulmonary embolism

  • I. Diagnosis and Treatment of Deep Venous Disease and Pulmonary Embolism
  • Published:
CardioVascular and Interventional Radiology Aims and scope Submit manuscript

Abstract

The troublesome sequelae of pulmonary embolism (PE) and deep vein thrombosis (DVT) justify an aggressive therapeutic approach. Results of anticoagulation in patients with DVT have shown that a significant percentage of patients have no clot resolution and may progress to develop the postphlebitic syndrome. Lytic therapy has been more effective, with patients showing improvement within 24 h of treatment. This approach has also been found to compare favorably with anticoagulation in the treatment of PE. Preliminary research also suggests a potential role for recombinant human tissue-type plasminogen activator to resolve PE.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Sherry S (1982) Clinical management of the thrombosed vessel: An overview. Angiology 33:6–10

    PubMed  CAS  Google Scholar 

  2. Elliot MS, Immelman EJ, Jeffery P (1979) Br J Surg 66:838–843

    Article  PubMed  CAS  Google Scholar 

  3. Arnesen H, Hoiseth A, Ly B (1982) Streptokinase or heparin in the treatment of deep vein thrombosis. Follow-up results of a prospective study. Acta Med Scand 211:65–68

    Article  PubMed  CAS  Google Scholar 

  4. Sharma GVRK, O'Connell DJ, Belko JS, Sasahara AA (1977) Thrombolytic therapy in DVT. In Paoletti R, Sherry S (eds): Thrombosis and urokinase. Academic, New York, p 181.

    Google Scholar 

  5. Graor RA, Young YR, Risius B, Ruschhaupt WF (1987) Cost-effective comparison of streptokinase and urokinase in the treatment of deep vein thrombosis. Ann Vasc Surg 1:524–528

    Article  PubMed  CAS  Google Scholar 

  6. Urokinase Pulmonary Embolism Trial Study Group (1974) Urokinase-streptokinase pulmonary embolism trial: Phase 2 results. JAMA 229:1606–1613

    Article  Google Scholar 

  7. Sharma GVRK, Burleson VA, Sasahara AA (1980) Effect of thrombolytic therapy on pulmonary capillary blood volume in patients with pulmonary embolism. New Engl J Med 303:842

    Article  PubMed  CAS  Google Scholar 

  8. Graor RA: Management of DVT & PE. J Vasc Surg (in press)

  9. Goldhaber SZ, Vaughan DE, Markis JE (1986) Acute pulmonary embolism treated with tissue plasminogen activator. Lancet 2:886–889

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Peripheral Vascular Diseases, Cleveland Clinic Foundation, 9500 Euclid Avenue, 44106, Cleveland, OH, USA

    Robert Graor M.D.

Authors
  1. Robert Graor M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Graor, R. Fibrinolytic therapy for deep vein thrombosis and pulmonary embolism. Cardiovasc Intervent Radiol 11 (Suppl 1), S33–S36 (1988). https://doi.org/10.1007/BF02577094

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02577094

Key words

Search

Navigation