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Mineralized tissue protein profiles in the Australian form of bovine osteogenesis imperfecta

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Summary

Noncollagenous proteins and proteoglycan from the bone and dentin of affected and normal half-siblings neonatal calves with the Australian variant of bovine osteogenesis imperfecta (BOI-A) were quantitated. In contrast to a clinically similar syndrome of BOI in the progeny of a second progenitor bull identified in Texas (BOI-T), osteonectin and bone sialoprotein levels were normal in the affected BOI-A bone, and dentin phosphophoryn levels were normal in affected BOI-A teeth. However, bone proteoglycan in the affected BOI-A calves was depleted to one-third of the level found in normal siblings, a finding qualitatively similar to the depletion of bone proteoglycan in the BOI-T syndrome. These results suggest that quantitation of noncollagenous proteins and proteoglycans may be a useful technique for differentiating clinically similar syndromes of OI in man.

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Authors and Affiliations

  1. Bone Research Branch, National Institute of Dental Research, National Institutes of Health, Bldg. 30, Room 106, 20892, Bethesda, Maryland

    Larry W. Fisher, Laurence J. Denholm, Kathleen M. Conn & John D. Termine

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  1. Larry W. Fisher
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  2. Laurence J. Denholm
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  3. Kathleen M. Conn
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  4. John D. Termine
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Fisher, L.W., Denholm, L.J., Conn, K.M. et al. Mineralized tissue protein profiles in the Australian form of bovine osteogenesis imperfecta. Calcif Tissue Int 38, 16–20 (1986). https://doi.org/10.1007/BF02556589

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  • DOI: https://doi.org/10.1007/BF02556589

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