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Protective effect of Verapamil on ischaemic renal injury in dogs

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Abstract

Three groups of female mongrel dogs were used. In each dog right nephrectomy was performed. In the first group, 60-min complete occlusion of the left renal artery was followed by 50.4% reduction in RBF (P<0.05), 53.4% reduction in GFR (P<0.01) and 46.7% reduction in urine flow rate (UV) (P<0.05). These haemodynamic changes were accompanied by a significant (P<0.01) increase in urinary enzyme activity. In the second group, following Verapamil 0.5 mg/kg i.v. bolus, there was diuresis and natriuresis, urine flow rate (UV) increased by 39% and UNaV by 60% (P>0.05); there were no changes in RBF or GFR. In the third group, pretreatment with Verapamil prior to the arterial occlusion modified the deleterious effects of the 60-min renal ischaemia. RBF decreased by 9.4%, GFR by 28.5% and UV by 11.1% (P>0.05); there was no change in the urinary enzyme activity. It is concluded that Verapamil can protect against ischaemic renal damage.

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  1. Urology and Nephrology Center, Mansoura University, Mansoura, Egypt

    M. A. Sobh & M. M. El-Sharabasy

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  1. M. A. Sobh
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  2. M. M. El-Sharabasy
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Sobh, M.A., El-Sharabasy, M.M. Protective effect of Verapamil on ischaemic renal injury in dogs. International Urology and Nephrology 19, 21–26 (1987). https://doi.org/10.1007/BF02549673

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  • DOI: https://doi.org/10.1007/BF02549673

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