Abstract
Labeled125I-PTH with full biological activity was utilized to investigate the interrelationship between vitamin D and parathyroid hormone (PTH) function. The distribution of labeled PTH was studied in rats and chickens on diets containing various amounts of vitamin D and calcium. The effects of vitamin D deficiency were found to be minor. There was a slightly delayed (10–30%) blood clearance of the hormone and a smaller deposition in the liver (20–30%) in the D-deficient animals. Deposition in bone and kidney appeared to be essentially normal. It is concluded that any failure of PTH to evoke a bone response in the deficient animal is not due to the failure of binding of hormone at the target organ.
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Neuman, M.W., Neuman, W.F. & Lane, K. The metabolism of labeled parathyroid hormone. Calc. Tis Res. 18, 289–295 (1975). https://doi.org/10.1007/BF02546247
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DOI: https://doi.org/10.1007/BF02546247