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Effect of platelet-activating factor on lipoprotein lipase and blood lipids

  • PAF and PAF Analogs and Their Metabolic Effects
  • Published:
Lipids

Abstract

We investigated the effect of platelet-activating factor (PAF) and of the PAF specific antagonist CV-6209 on plasma lipid metabolism, and particularly on post-heparin plasma lipolytic activity in male Wistar rats. Lipoprotein lipase (LPL) activity was enhanced by intravenous injection of PAF before intravenous injection of heparin when the PAF dose was low (0.2 μg/kg). PAF activated hepatic triacylglycerol lipase (HTGL) activity dose-dependently. Plasma triacylglycerols (TG) significantly decreased with the activation of LPL and/or HTGL. Plasma total cholesterol (TC) and phospholipid (PL) levels decreased at a low dose of PAF (0.2 μg/kg), but increased when higher doses were used. The PAF antagonist CV-6209 partially reversed the PAF induced effects on HTGL, TC and PL.

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Abbreviations

FFA:

free fatty acids

HTGL:

hepatic triacylglycerol lipase

LDL:

low density lipoprotein

LPL:

lipoprotein lipase

MDA:

malondialdehyde

PAF:

platelet-activating factor

PL:

phospholipid

TC:

total cholesterol

TG:

triacylglycerols

VLDL:

very low density lipoprotein

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Authors and Affiliations

  1. Third Department of Internal Medicine, Wakayama Medical University, 640, Wakayama, Japan

    Keiji Mimura, Susumu Yukawa, Yoshio Mori, Kazuya Okada, Masatoshi Mune, Osamu Nishikawa, Akira Hibino, Miyahiko Sonobe, Tetuya Goto & Hiroshi Nomoto

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  1. Keiji Mimura
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  2. Susumu Yukawa
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  3. Yoshio Mori
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  4. Kazuya Okada
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  5. Masatoshi Mune
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  6. Osamu Nishikawa
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  7. Akira Hibino
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  8. Miyahiko Sonobe
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  9. Tetuya Goto
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  10. Hiroshi Nomoto
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Mimura, K., Yukawa, S., Mori, Y. et al. Effect of platelet-activating factor on lipoprotein lipase and blood lipids. Lipids 26, 1102–1107 (1991). https://doi.org/10.1007/BF02536510

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  • DOI: https://doi.org/10.1007/BF02536510

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