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Intake of different eicosapentaenoic acid-containing lipids and fatty acid pattern of plasma lipids in the rats

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Lipids

Abstract

The ethyl ester of eicosapentaenoic acid (EPA) is the only pure EPA-containing lipid available in bulk for oral administration. However, there is doubt as to whether EPA ethyl ester can efficiently increase the plasma levels of EPA in comparison with the ability of other kinds of EPA-containing lipids to do so. Therefore, two other kinds of EPA-containing lipids were prepared to study the efficiency of oral administration of those lipids for increasing the EPA content in plasma phospholipids and cholesteryl esters. EPA-containing lipids which were investigated were [A], 1,2,3-trieicosapentaenoyl-glycerol, [B] 2-eicosapentaenoyl-phosphatidylcholine and [C] ethyl ester of EPA. An adjusted amount of lipids [A], [B] and [C] was administered to rats through a gastric tube for 4 days (the first experiment) or for 10 days (the second experiment), and the fatty acid composition of plasma phospholipids and cholesteryl esters was determined. In the first experiment, there were no significant differences in the efficiency for increasing EPA levels in either phospholipids or cholesteryl esters among the lipids. In the second experiment, the EPA levels of both plasma phospholipids and cholesteryl esters of rats administered ethyl ester of EPA were significantly higher than those of rats administered 2-eicosapentaenoyl-phosphatidylcholine. The EPA levels of the rats administered 1,2,3-trieicosapentaenoylglycerol were between the levels of the two groups mentioned above, but the differences in the EPA levels were not significant. Although an ethyl ester-type molecule is not a naturally occurring lipid, ethyl ester of EPA is equal to 1,2,3-trieicosapentaenoyl-glycerol and appears to be superior to 2-eicosapentaenoyl-phosphatidylcholine as to the efficiency for increasing EPA levels in total plasma phospholipids and plasma cholesteryl esters.

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Abbreviations

AA:

arachidonic acid

CE:

cholesteryl esters

EE:

ethyl ester

EPA:

eicosapentaenoic acid

PC:

phosphatidylcholine

PL:

phospholipids

TG:

triglycerides

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Authors and Affiliations

  1. Central Research Laboratory, Nippon Suisan Kaisha, Ltd., Hachioji City, Tokyo, Japan

    Masahiro Makuta & Akio Ozawa

  2. Medical and Pharmaceutical Laboratory, Nippon Shoji Co., Ltd., Ibaraki City, Osaka, Japan

    Yasuji Soda & Hiroshi Tatsumi

  3. Toyama Medical and Pharmaceutical University, Toyoma City, Japan

    Akira Kumagai

  4. 1st Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 930-01, Toyama City, Japan

    Tomohito Hamazaki, Masaharu Urakaze & Saburo Yano

Authors
  1. Tomohito Hamazaki
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  2. Masaharu Urakaze
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  3. Masahiro Makuta
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  4. Akio Ozawa
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  5. Yasuji Soda
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  6. Hiroshi Tatsumi
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  7. Saburo Yano
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  8. Akira Kumagai
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Hamazaki, T., Urakaze, M., Makuta, M. et al. Intake of different eicosapentaenoic acid-containing lipids and fatty acid pattern of plasma lipids in the rats. Lipids 22, 994–998 (1987). https://doi.org/10.1007/BF02536438

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  • DOI: https://doi.org/10.1007/BF02536438

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