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α-Oxidation of α-hydroxyfatty acids in rat brain. Possible involvement of an α-peroxylactone

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Lipids

Abstract

Combine—but not individual—microsomal and supernatant fractions obtained from rat brains not only consume oxygen but also provoke emission from added chlorophyll. These results are consistent with literature data (Levis and Mead,J. Biol. Chem. 239, 77 [1964]) for trapping of radioactive14CO2 following addition of α-hydroxy-[1-14C]stearic acid. The most plausible explanation for emission is the interaction of chlorophyll with an α-peroxylactone. An intermediary α-peroxylactone in α-oxidation is consistent with other available data (Salim-Hanna, Campa and Cilento,Photochem. Photobiol. 45, 849 [1987]; Campa, Salim-Hanna and Cilento,Photochem. Photobiol. 49, 349 [1989]) and, on chemical grounds, provides a feasible route to the final products.

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Abbreviations

ATP:

adenosine triphosphate

CIEEL:

chemically initiated electron exchange luminescence

EDTA:

ethylenediamine tetracetic acid

References

  1. Martin, R.O., and Stumpf, P.K. (1959)J. Biol. Chem. 234 2548–2554.

    PubMed  CAS  Google Scholar 

  2. Shine, W.E., and Stumpf, P.K. (1974)Arch. Biochem. Biophys. 162, 147–157.

    Article  PubMed  CAS  Google Scholar 

  3. Salim-Hanna, M., Campa, A., and Cilento, G. (1987)Photochem. Photobiol. 45, 849–854.

    CAS  Google Scholar 

  4. Campa, A., Salim-Hanna, M., and Cilento, G. (1989)Photochem. Photobiol. 49, 349–354.

    CAS  Google Scholar 

  5. Schmidt, S.P., and Schuster, G.B. (1980)J. Am. Chem. Soc. 102, 7100–7103.

    Article  CAS  Google Scholar 

  6. Levis, G.M., and Mead, J.F. (1964)J. Biol. Chem. 239, 77–80.

    PubMed  CAS  Google Scholar 

  7. Kindl, H. (1984) inFatty Acid Metabolism and Its Regulation (Numa, S., ed.) pp. 181–204, Elsevier, Amsterdam, The Netherlands.

    Google Scholar 

  8. Vernon, L.P. (1960)Anal. Chem. 32, 1144–1150.

    Article  CAS  Google Scholar 

  9. Cilento, G. (1984)Pure Appl. Chem. 56, 1179–1190.

    CAS  Google Scholar 

  10. Lissi, E.A., Cãceres, T., and Videla, L.A. (1988)Free Rad. Biol. Med. 4, 93–97.

    Article  PubMed  CAS  Google Scholar 

  11. Adam, W. (1982) inChemical and Biological Generation of Excited States (Adam, W. and Cilento, G., eds.) pp. 115–152, Academic Press, New York.

    Google Scholar 

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Author notes

  1. Marta Salim-Hanna

    Present address: Departmento de Química, Universidad de Santiago de Chile, Santiago, Chile

  2. Ana Campa

    Present address: Department of Clinical Analysis. Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, C.P. 30786, CEP 01051, São Paulo, Brazil

Authors and Affiliations

  1. Department of Biochemistry, Instituto de Quimica, Universidade de São Paulo, C.P. 20780, 01498, Sao Paulo, Brazil

    Marta Salim-Hanna, Ana Campa & Giuseppe Cilento

Authors
  1. Marta Salim-Hanna
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  2. Ana Campa
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  3. Giuseppe Cilento
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Salim-Hanna, M., Campa, A. & Cilento, G. α-Oxidation of α-hydroxyfatty acids in rat brain. Possible involvement of an α-peroxylactone. Lipids 24, 750–752 (1989). https://doi.org/10.1007/BF02535217

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  • DOI: https://doi.org/10.1007/BF02535217

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