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The incorporation of 2-aminoethylphosphonic acid into rat liver diacylglyceroaminoethylphosphonate

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Lipids

Abstract

Rats intravenously administered (14C) 2-aminoethylphosphonic acid (AEP) incorporated ca. 16% of the total injected compound into liver lipids. Thin layer chromatography and selective chemical and enzymatic hydrolysis of the labeled lipids demonstrated that essentially all of the radioactivity was in one compound, diacylglycerol-AEP, the phosphonate analog of phosphatidylethanolamine. Lipids from kidneys, heart, skeletal muscle, adipose, pancreas and brain were examined and found to contain less than 2% collectively of the total injected radioactivity. The residues from the tissues contained ca. 3.2% of the total injected (14C) AEP.

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References

  1. Horiguchi, M., and M. Kandatsu, Nature 184:901 (1959).

    Article  PubMed  CAS  Google Scholar 

  2. Quin, L.D., in “Topics in Phosphorus Chemistry,” Vol. 4, Edited by M. Grayson and E.J. Griffith, Interscience Publishers, New York, 1967, p. 23.

    Google Scholar 

  3. Kittredge, J.S., and E. Roberts, Science 164:37 (1969).

    Article  PubMed  CAS  Google Scholar 

  4. Kandatsu, M., and M. Horiguchi, Agr. Biol. Chem. Tokyo 29:781 (1965).

    CAS  Google Scholar 

  5. Shimizu, H., Y. Kakimoto, T. Nakajima, A. Kanazawa and I. Sano, Nature 207:1198 (1965).

    Article  Google Scholar 

  6. Alhadeff, J.A., and G.D. Daves, Jr., Biochemistry 9:4866 (1970).

    Article  PubMed  CAS  Google Scholar 

  7. Alam, A.U., and S.H. Bishop, “156th American Chemical Society Meeting,” September 1968, Abstr. 276.

  8. Kandatsu, M., M. Horiguchi and M. Tamari, Agr. Biol. Chem. Tokyo 29:779 (1965).

    CAS  Google Scholar 

  9. Kosolapoff, G.M., J. Amer. Chem. Soc. 69:2112 (1947).

    Article  Google Scholar 

  10. Smith, J.D., and J.H. Law, Biochemistry 9:2152 (1970).

    Article  PubMed  CAS  Google Scholar 

  11. Folch, P., M. Lees and G.H. Sloan-Stanley, J. Biol. Chem. 226:497 (1957).

    PubMed  CAS  Google Scholar 

  12. Henderson, T.O., J.J. McNeill and S.B. Tove, J. Bacteriol. 90:1283 (1965).

    PubMed  CAS  Google Scholar 

  13. Wagner, H., L. Horbammer and P. Wolfe, Biochem. Z. 334:175 (1961).

    PubMed  CAS  Google Scholar 

  14. Thompson, G.A., Jr., Biochim. Biophys. Acta 176:330 (1969).

    PubMed  CAS  Google Scholar 

  15. Hori, T., M. Sugita and O. Itakaki, J. Biochem. Tokyo 65:451 (1969).

    PubMed  CAS  Google Scholar 

  16. Snyder, W.R., and J.H. Law, Lipids 5:800 (1970).

    Article  PubMed  CAS  Google Scholar 

  17. Dittmer, J.C., and R.L. Lester, J. Lipid Res. 5:126 (1964).

    CAS  Google Scholar 

  18. White, D.C., and R.H. Cox, J. Bacteriol. 93:1079 (1967).

    PubMed  CAS  Google Scholar 

  19. Yang, S.F., S. Freer and A.A. Benson, J. Biol. Chem. 242:477 (1967).

    PubMed  CAS  Google Scholar 

  20. Hildebrand, J.G., and J.H. Law, Biochemistry 3:1304 (1964).

    Article  PubMed  CAS  Google Scholar 

  21. Smith, J.D., and J.H. Law, Biochim. Biophys. Acta 202:141 (1970).

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Biological Chemistry, University of Illinois Medical Center, 60612, Chicago, Illinois

    Jean M. Curley & Thomas O. Henderson

Authors
  1. Jean M. Curley
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  2. Thomas O. Henderson
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Curley, J.M., Henderson, T.O. The incorporation of 2-aminoethylphosphonic acid into rat liver diacylglyceroaminoethylphosphonate. Lipids 7, 676–679 (1972). https://doi.org/10.1007/BF02533076

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  • DOI: https://doi.org/10.1007/BF02533076

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