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Metabolic control in isolated brown fat cells

  • Published:
Lipids

Abstract

Experiments with brown fat cell preparations from the adult hamsters are described. The mitochondria of brown adipose tissue were shown to have a classical electron transport system. The basal respiration of brown fat cells was demonstrated to be coupled to oxidative phosphorylation. Evidence is presented for partial uncoupling of oxidative phosphorylation as a mechanism for controlling respiration during norepinephrine stimulation. Exogenously added fatty acids were found to mimick the norepinephrine stimulation of respiration. Norepinephrine and cyclic AMP were shown to have no effect on brown fat mitochondria. Experiments with labeled oleate showed that the triglyceride reesterification cycle does not control respiration in brown adipose tissue.

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Author information

Author notes

  1. Stanley B. Prusiner (Fellow of Medical Student Research Training Programs)

    Present address: University of Pennsylvania, Philadelphia, Pa

  2. Te May Ching

    Present address: Oregon State University, Corvallis, Oregon

  3. R. H. Eisenhardt

    Present address: Harrison Department of Surgical Research, University of Pennsylvania, Philadelphia, Pa

Authors and Affiliations

  1. Wenner-Gren Institute, University of Stockholm, Stockholm, Sweden

    Olov Lindberg, Stanley B. Prusiner (Fellow of Medical Student Research Training Programs), Barbara Cannon, Te May Ching & R. H. Eisenhardt

Authors
  1. Olov Lindberg
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  2. Stanley B. Prusiner
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  3. Barbara Cannon
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  4. Te May Ching
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  5. R. H. Eisenhardt
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Additional information

One of nine papers to be published from the Symposium “Brown Adipose Tissue,” presented at the AOCS-AACC Joint Meeting, Washington, D.C., March 1968.

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Lindberg, O., Prusiner, S.B., Cannon, B. et al. Metabolic control in isolated brown fat cells. Lipids 5, 204–209 (1970). https://doi.org/10.1007/BF02532470

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  • DOI: https://doi.org/10.1007/BF02532470

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