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Inhibition of enzymatic reduction of Δ14-double bond of 5α-cholesta-8,14-dien-3β-ol and 5α-cholesta-7,14-dien-3β-ol by AY-9944

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Lipids

Abstract

AY-994 (trans-1,4-bis-[2-chlorobenzyl-aminomethyl] cyclohexane dihydrochloride), a potent inhibitor of the enzymatic reduction of the Δ7-double bond of Δ5,7-sterols, has been shown to inhibit, at higher concentrations (10−4 M), the enzymatic reduction of the Δ14-double bond of cholesta-8,14-dien-3β-ol and cholesta-7,14-dien-3β-ol.

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Author notes

  1. B. N. Lutsky

    Present address: Schering Corp, 07003, Bloomfield, New Jersey

Authors and Affiliations

  1. School of Chemical Sciences, University of Illinois, 61801, Urbana, Illinois

    B. N. Lutsky, Hansen M. Hsiung & G. J. Schroepfer Jr.

  2. Department of Biochemistry, Rice University, 77001, Houston, Texas

    B. N. Lutsky, Hansen M. Hsiung & G. J. Schroepfer Jr.

Authors
  1. B. N. Lutsky
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  2. Hansen M. Hsiung
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  3. G. J. Schroepfer Jr.
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Lutsky, B.N., Hsiung, H.M. & Schroepfer, G.J. Inhibition of enzymatic reduction of Δ14-double bond of 5α-cholesta-8,14-dien-3β-ol and 5α-cholesta-7,14-dien-3β-ol by AY-9944. Lipids 10, 9–11 (1975). https://doi.org/10.1007/BF02532186

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  • DOI: https://doi.org/10.1007/BF02532186

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