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Synthesis and Pharmacological Activity of 3-Phenoxybenzoic Acid Derivatives

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Pharmaceutical Chemistry Journal Aims and scope

3-Phenoxybenzoic acid derivatives were synthesized. Their pharmacological activity was studied. Several compounds, in particular 2-cyanoprop-2-yl 3-phenoxybenzoate, were found to exhibit peroxisome proliferator-activated receptor γ agonist activity and to be capable of activating glucokinase and inhibiting protein glycation. The studied compounds did not influence dipeptidyl peptidase-4 activity.

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Acknowledgments

The research was sponsored by a Russian Science Foundation Grant (Project No. 14-25-00139).

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Authors and Affiliations

  1. Volgogard State Medical University, Volgograd, 400131, Russia

    A. A. Spasov, V. S. Lobasenko, V. A. Kosolapov, D. A. Babkov, V. A. Kuznetsova, O. Yu. Maika & Yu. V. Popov

  2. Volgograd State Technical University, Volgograd, 400005, Russia

    T. K. Korchagina

Authors
  1. A. A. Spasov
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  2. V. S. Lobasenko
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  3. V. A. Kosolapov
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  4. D. A. Babkov
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  5. V. A. Kuznetsova
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  6. O. Yu. Maika
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  7. Yu. V. Popov
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  8. T. K. Korchagina
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Corresponding author

Correspondence to A. A. Spasov.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 3, pp. 20 – 26, March, 2020.

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Spasov, A.A., Lobasenko, V.S., Kosolapov, V.A. et al. Synthesis and Pharmacological Activity of 3-Phenoxybenzoic Acid Derivatives. Pharm Chem J 54, 229–235 (2020). https://doi.org/10.1007/s11094-020-02185-z

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  • DOI: https://doi.org/10.1007/s11094-020-02185-z

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