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Cytotoxic 5α,8α-epidioxy sterols from the marine sponge Monanchora sp.

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Abstract

Three new sterols, 5α,8α-epidioxy-24-norcholesta-6,9(11),22-trien-3β-ol (1), 5α,8α-epidioxy-cholesta-6,9(11),24-trien-3β-ol (2), and 5α,8α-epidioxy-cholesta-6,23-dien-3β,25-diol (3), with four known sterols (4–7) were isolated from a marine sponge Monanchora sp. Their chemical structures were elucidated by extensive spectroscopic analysis. Compounds 1 and 3–7 showed moderate cytotoxicity against several human carcinoma cell lines including renal (A-498), pancreatic (PANC-1 and MIA PaCa-2), and colorectal (HCT 116) cancer cell lines.

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Acknowledgments

This work was supported by the Marine Biotechnology Program, Ministry Oceans and Fisheries and by the 2012 Yeungnam University Research Grant. B. Mun, H. Kim, D. Hahn, J. Lee were in part supported by the BK21 program, Ministry of Education, Korea.

Conflict of interest

All the authors have no conflict of interest to declare.

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Authors and Affiliations

  1. Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul, 151-747, Republic of Korea

    Bora Mun, Weihong Wang, Hiyoung Kim, Dongyup Hahn, Inho Yang, Dong Hwan Won, Eun-hee Kim, Jihye Lee, Chulkyeong Han, Hyunji Kim & Heonjoong Kang

  2. Queensland Museum, South Brisbane BC, QLD, 4101, Australia

    Merrick Ekins

  3. Department of Chemistry and Nano Science, Ewha Womans University, Seoul, 120-750, Republic of Korea

    Sang-Jip Nam

  4. College of Pharmacy, Yeungnam University, 280, Daehak-ro, Gyeongsan, 712-749, Republic of Korea

    Hyukjae Choi

  5. Research Institute of Oceanography, Seoul National University, NS-80, Seoul, 151-747, Republic of Korea

    Heonjoong Kang

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  1. Bora Mun
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  2. Weihong Wang
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  3. Hiyoung Kim
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  7. Eun-hee Kim
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  10. Hyunji Kim
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  13. Hyukjae Choi
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  14. Heonjoong Kang
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Correspondence to Hyukjae Choi or Heonjoong Kang.

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Mun, B., Wang, W., Kim, H. et al. Cytotoxic 5α,8α-epidioxy sterols from the marine sponge Monanchora sp.. Arch. Pharm. Res. 38, 18–25 (2015). https://doi.org/10.1007/s12272-014-0480-8

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  • DOI: https://doi.org/10.1007/s12272-014-0480-8

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