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Fatty acid composition of free ceramides of kidney and cerebellum from a patient with Farber's disease

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Lipids

Abstract

The fatty acid composition of ceramides has been determined in kidney and cerebellum of a patient with Farber's disease, which is characterized by ceramidase deficiency. Farber cerebellum and kidney contained a five- and ten-fold excess, respectively, of free ceramides. The nonhydroxy fatty acid patterns of the ceramides from Farber kidney and cerebellum showed considerable similarities to those from control tissues, whereas large amounts of ceramides containing hydroxy fatty acids are found in Farber's disease tissues.

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Author notes

  1. M. Sugita

    Present address: Dept. of Chemistry, Shiga University, Ohtsu, Shiga, Japan

Authors and Affiliations

  1. Eunice Kennedy Shriver Center, Walter E. Fernald State School, Box C, 02178, Massachusetts, Waverley

    M. Sugita, P. Connolly, J. T. Dulaney & H. W. Moser

Authors
  1. M. Sugita
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  2. P. Connolly
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  3. J. T. Dulaney
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  4. H. W. Moser
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Sugita, M., Connolly, P., Dulaney, J.T. et al. Fatty acid composition of free ceramides of kidney and cerebellum from a patient with Farber's disease. Lipids 8, 401–406 (1973). https://doi.org/10.1007/BF02531715

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  • DOI: https://doi.org/10.1007/BF02531715

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