Skip to main content
SpringerLink
Log in

The interactions of99mTc phosphorus radiopharmaceuticals and human serum proteins

  • Medical Radionuclides and the Quality of Radiopharmaceuticals
  • Published:
Journal of Radioanalytical Chemistry Aims and scope Submit manuscript

Abstract

Dialysis and precipitation methods have been used to study the binding affinity of selected technetium-99m phosphorus radiopharmaceuticals to human serum proteins. The binding affinities of three different99mTc bone imaging agents were found to be inversely related to their respective clearance rates from blood in vivo. The binding order showed99mTcPPi>99mTcHEDP>99mTcMDP. The99mTc phosphorus radiopharmaceuticals were bound primarily to alpha globulins. The results suggest that the binding of99mTc phosphorus radiopharmaceuticals to human serum proteins in blood is largely determined by their affinities to the alpha globulins.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. G. T. KRISHNAMURTHY, R. J. HUEBOTTER, C. F. WALSH et al., J. Nucl. Med., 16 (1975) 109.

    CAS  Google Scholar 

  2. G. T. KRISHNAMURTHY, P. B. THOMAS, M. TUBIS et. al., J. Nucl. Med., 15 (1974) 832.

    CAS  Google Scholar 

  3. G. SUBRAMANIAN, J. G. MCAFEE, R. J. BLAIR et. al., J. Nucl. Med., 16 (1975) 744.

    CAS  Google Scholar 

  4. A. GOLDSTEIN, Pharmacol. Rev. (1949) 103.

  5. A. J. TOFE, M. D. FRANCIS, J. Nucl. Med., 15 (1974) 69.

    CAS  Google Scholar 

  6. M. K. DEWANJEE, P. BRUEGGEMAN, In Radiopharmaceuticals, Vol. 2, Proc. 2nd Intern. Symp. on Radiopharmaceuticals, Seattle, Washington (1979) p. 435.

  7. A. OWUNWANNE, R. E. O'MARA, C. O'BRIEN, J. Radioanal. Chem., 59 (1980) 571.

    Article  CAS  Google Scholar 

  8. C. SCHÜMICHEN, K. KOCH, A. KRAUS et al., J. Nucl. Med., 21 (1980) 1080.

    Google Scholar 

  9. B. A. ASHTON, J. J. HOHLING, J. T. TRIFFITT, Calcif. Tiss. Res., 22 (1976) 27.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University of Rochester School of Medicine and Dentistry, Rochester, New York, (USA)

    A. Owunwanne, R. E. O'Mara, D. A. Weber & G. A. Wilson

Authors
  1. A. Owunwanne
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. E. O'Mara
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. A. Weber
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. A. Wilson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Owunwanne, A., O'Mara, R.E., Weber, D.A. et al. The interactions of99mTc phosphorus radiopharmaceuticals and human serum proteins. J. Radioanal. Chem. 74, 293–299 (1982). https://doi.org/10.1007/BF02520380

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02520380

Keywords

Search

Navigation