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The stability of99mTc phosphorus compounds in plasma both in vivo and in vitro

  • Medical Radioisotopes and Control of Radiopharmaceuticals
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Abstract

The in vivo and in vitro stability of99mTc hydroxyethlylidene diphosphonate, 99mTc methylenediphosphonate and99mTc pyrophosphate in plasma has been studied using paper chromatographic technique as the analytical tool. The results indicate that the amounts of99mTc activity found both at the origin and Rf range of99mTcO4 − for in vivo experiments are slightly greater than those for either in vitro or control experiments. However, this amount of99mTc activity represents about 0.16–0.4% of the injected dose. Therefore, it is suggested that99mTc phosphorus radiopharmaceuticals are stable in vivo and neither oxidation nor hydrolysis of these bone imaging agents occurs in the blood.

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References

  1. A. G. JONES, M. D. FRANCIS, M. A. DAVIS, Sem. Nucl. Med., 6 (1976) 3.

    CAS  Google Scholar 

  2. R. E. ACKERHALT, M. BLAU, S. BAKSHI, et al., J. Nucl. Med., 15 (1974) 1153.

    CAS  Google Scholar 

  3. D. A. WEBER, J. W. KEYES, JR., G. A. WILSON, et al., Radiology, 120 (1976) 615.

    CAS  Google Scholar 

  4. G. SUBRAMANIAN, J. G. McAFEE, R. J. BLAIR, et al., In Radiopharmaceuticals G. SUBRAMANIAN, B. A. RHODES, J. F. COOPER, V. J. SODD (Eds), New York, The Society of Nuclear Medicine, Inc., 1975, p. 319.

    Google Scholar 

  5. G. T. KRISHNAMURTHY, M. TUBIS, I. S. I. S. ENDOW, et al., J. Nucl. Med., 15 (1974) 848.

    CAS  Google Scholar 

  6. P. L. ALTMAN, D. S. DITTMER (Eds), Biological Hand Books. Blood and Other Body Fluids, Federation of American Societies for Experimental Biology, Maryland, 1971, pp. 76, 94.

    Google Scholar 

  7. M. K. DEWANJEE, P. BRUGGEMANN, In Radiopharmaceuticals II: Proceedings, 2nd Int'l Symp. on Radiopharmaceuticals. Seattle, Washington, 1979, p. 435.

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Authors and Affiliations

  1. University of Rochester School of Medicine and Dentistry, Rochester, New York, (USA)

    A. Owunwanne, R. E. O'Mara & C. O'Brien

Authors
  1. A. Owunwanne
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  2. R. E. O'Mara
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  3. C. O'Brien
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Owunwanne, A., O'Mara, R.E. & O'Brien, C. The stability of99mTc phosphorus compounds in plasma both in vivo and in vitro. J. Radioanal. Chem. 59, 571–578 (1980). https://doi.org/10.1007/BF02517301

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  • DOI: https://doi.org/10.1007/BF02517301

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