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Catalytic antibodies as a new generation of biocatalysts

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Abstract

The present state and perspectives of the creation of a new generation of biocatalysts, catalytic antibodies (CA), and their application to organic synthesis are discussed. The problems to be solved for the development of the practical application of CA are especially noted.

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References

  1. A. Tramontano, K. Janda, and R. Lerner,Science, 1986,234, 1566.

    Article  CAS  Google Scholar 

  2. S. Pollack, J. Jacobs, and P. Schultz,Science, 1986,234, 1570.

    Article  CAS  Google Scholar 

  3. R. Lerner, S. Benkovic, and P. Schultz,Science, 1991,252, 659.

    Article  CAS  Google Scholar 

  4. D. Kohler and C. Milstein,Nature, 1975,256, 495;

    Article  CAS  Google Scholar 

  5. E. Engvall,Methods Enzymol., 1990,20, 419.

    Google Scholar 

  6. K. Janda, S. Benkovic, and R. Lerner,Science, 1989,244, 437.

    Article  CAS  Google Scholar 

  7. K. Janda, et al.,J. Am. Chem. Soc., 1991,113, 291.

    Article  CAS  Google Scholar 

  8. T. Kitazume, J. Lin, M. Takeda, and T. Yamarani,J. Am. Chem. Soc., 1991,113, 2123.

    Article  CAS  Google Scholar 

  9. Y. Iwabuchi, H. Miyashita, R. Tanimura, K. Kinoshita, M. Kikuchi, and J. Fujii,J. Am. Chem. Soc., 1994,116, 771.

    Article  CAS  Google Scholar 

  10. K. Janda, D. Schloeder, S. Benkovic, and R. Lerner,Science, 1988,241, 1188.

    Article  CAS  Google Scholar 

  11. B. Iversen and R. Lerner,Science, 1989,243, 1184.

    Article  Google Scholar 

  12. S. Benkovic, A. Napper, and R. Lerner,Proc. Nat. Acad. Sci. USA, 1988,85, 5355.

    Article  CAS  Google Scholar 

  13. T. Li, K. Janda, J. Ashley, and R. Lerner,Science, 1994,264, 1289.

    Article  CAS  Google Scholar 

  14. A. Braisted and P. Schultz,J. Am. Chem. Soc., 1990,112, 7430.

    Article  CAS  Google Scholar 

  15. D. Jackson, J. Jacobs, R. Sugasawara, S. Reich, P. Bartlet, and P. Schultz,J. Am. Chem. Soc., 1988,110, 4841.

    Article  CAS  Google Scholar 

  16. A. Braisted and P. Schultz,J. Am. Chem. Soc., 1994,116, 2211.

    Article  CAS  Google Scholar 

  17. K. Janda, Ch. Shevlein, and R. Lerner,Science, 1993,259, 490.

    Article  CAS  Google Scholar 

  18. B. Cravatt, J. Ashley, K. Janda, D. Boger, and R. Lerner,J. Am. Chem. Soc., 1994,116, 6013.

    Article  CAS  Google Scholar 

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This paper was prepared in response to a request from the Editorial board in order to attract the attention of investigators to the creation of artificial enzymes, called catalytic antibodies, which is a new and important direction in science.

Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 9, pp. 1568–1574, September, 1997

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Kochetkov, N.K. Catalytic antibodies as a new generation of biocatalysts. Russ Chem Bull 46, 1495–1500 (1997). https://doi.org/10.1007/BF02502927

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  • DOI: https://doi.org/10.1007/BF02502927

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