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Comparative study of antitumor cytostatic and natural suppressor activity of bone marrow cells

  • Microbiology and Immunology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Cells remaining after removal from bone marrow population of cells aggregated by wheat rudiment agglutinin retained the capacity to inhibit the growth of P815 mastocytoma and L1210 lymphoma cellsin vitro, while their capacity to suppress concanavalin-induced lymphoblastogenesis dropped. Contrary to antiproliferative activity of bone marrow natural suppressor cells, their natural antitumor cytostatic activity did not depend on the presence of interferon-γ in the medium and was not mediated by nitric oxide. Thus, bone marrow antitumor cytostatic effectors are probably not equivalent to bone marrow natural suppresser cells by cell composition and by the mechanism of antiproliferative effect.

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Authors and Affiliations

  1. Institute of Clinical Immunology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk

    V. I. Seledtsov, G. V. Seledtsova, V. Ya. Taraban, V. V. Senyukov, D. M. Samarin, O. V. Poveshchenko, E. A. Kashchenko & V. A. Kozlov

Authors
  1. V. I. Seledtsov
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  2. G. V. Seledtsova
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  3. V. Ya. Taraban
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  4. V. V. Senyukov
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  5. D. M. Samarin
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  6. O. V. Poveshchenko
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  7. E. A. Kashchenko
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  8. V. A. Kozlov
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 4, pp. 437–439, April, 1998

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Seledtsov, V.I., Seledtsova, G.V., Taraban, V.Y. et al. Comparative study of antitumor cytostatic and natural suppressor activity of bone marrow cells. Bull Exp Biol Med 125, 387–389 (1998). https://doi.org/10.1007/BF02499166

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  • DOI: https://doi.org/10.1007/BF02499166

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