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Interleukin-2 and staurosporin cancel inhibition of nonspecific cytotoxicity of rat splenocytes by high doses of phorbolmyristate acetate

  • Biophysics and Biochemistry
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Experiments with human erythromyeloleukemic K562 cells as target cells demonstrate that nonspecific cytotoxic activity of rat splenocytes suppressed by 1-day incubation of cells with phorbol-12-myristate-13-acetate is restored by subsequent 3-day incubation with interleukin-2 and staurosporin. Combined effects of both drugs during this incubation time decrease cell permeability for Trypan Blue by 50%.

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Authors and Affiliations

  1. Department of Biochemistry, Petrozavodsk State University, Petrozavodsk, USSR

    A. G. Anisimov & I. A. Bolotnikov

Authors
  1. A. G. Anisimov
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  2. I. A. Bolotnikov
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 3, pp. 300–303, March, 1998

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Anisimov, A.G., Bolotnikov, I.A. Interleukin-2 and staurosporin cancel inhibition of nonspecific cytotoxicity of rat splenocytes by high doses of phorbolmyristate acetate. Bull Exp Biol Med 125, 265–267 (1998). https://doi.org/10.1007/BF02496877

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  • DOI: https://doi.org/10.1007/BF02496877

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