Bulletin of Experimental Biology and Medicine

, Volume 125, Issue 2, pp 135–138 | Cite as

Influence of fibrinolysis system on ADP- and serotonin-induced aggregation of human platelets

  • M. Yu. Men'shikov
Biophysics and Biochemistry


Urokinase, a component of the fibrinolytic system, induces a time-dependent decrease in platelet aggregation activated by ADP and serotonin. Significant inhibition of ADP-induced aggregation was observed on the 30th–60th min and serotonin-induced on the 3th–10th min of preincubation with urokinase and depended on urokinase concentration. The plasmin inhibitor aprotinin partially abolished urokinase-induced reduction of the amplitude and rate of ADP-induced aggregation and had no effect on serotonin-induced aggregation. Our results favor multiple mechanisms of urokinase influence on platelet activity.

Key Words

urokinase platelets aggregation 


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Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • M. Yu. Men'shikov
    • 1
  1. 1.Institute of Cardiology, Cardiology Research CenterMinistry of HealthMoscow

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