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Influence of fibrinolysis system on ADP- and serotonin-induced aggregation of human platelets

  • Biophysics and Biochemistry
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Urokinase, a component of the fibrinolytic system, induces a time-dependent decrease in platelet aggregation activated by ADP and serotonin. Significant inhibition of ADP-induced aggregation was observed on the 30th–60th min and serotonin-induced on the 3th–10th min of preincubation with urokinase and depended on urokinase concentration. The plasmin inhibitor aprotinin partially abolished urokinase-induced reduction of the amplitude and rate of ADP-induced aggregation and had no effect on serotonin-induced aggregation. Our results favor multiple mechanisms of urokinase influence on platelet activity.

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Authors and Affiliations

  1. Institute of Cardiology, Cardiology Research Center, Ministry of Health, Moscow

    M. Yu. Men'shikov

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  1. M. Yu. Men'shikov
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 2, pp. 158–161, February, 1998

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Men'shikov, M.Y. Influence of fibrinolysis system on ADP- and serotonin-induced aggregation of human platelets. Bull Exp Biol Med 125, 135–138 (1998). https://doi.org/10.1007/BF02496840

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  • DOI: https://doi.org/10.1007/BF02496840

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