Influence of fibrinolysis system on ADP- and serotonin-induced aggregation of human platelets
- 20 Downloads
Urokinase, a component of the fibrinolytic system, induces a time-dependent decrease in platelet aggregation activated by ADP and serotonin. Significant inhibition of ADP-induced aggregation was observed on the 30th–60th min and serotonin-induced on the 3th–10th min of preincubation with urokinase and depended on urokinase concentration. The plasmin inhibitor aprotinin partially abolished urokinase-induced reduction of the amplitude and rate of ADP-induced aggregation and had no effect on serotonin-induced aggregation. Our results favor multiple mechanisms of urokinase influence on platelet activity.
Key Wordsurokinase platelets aggregation
Unable to display preview. Download preview PDF.
- 3.M. Yamaguchi, L. A. Bunce, L. A. Sporn, and C. W. Francis,Blood,84, No. 4, 1143–1150 (1994).Google Scholar
- 8.R. Paolini, A. Casonato, G. Boeri,et al., J. Med.,2, No. 2-3, 113–130, (1993).Google Scholar
- 9.B. Pasche, H. Ouimet, and S. Francis,J. Loscalzo, Blood,83, No. 2, 404–414 (1994).Google Scholar
- 10.W. F. Penny and J. A. Ware,,79, No. 1, 91–98 (1992).Google Scholar
- 11.B. D. Royston, D. Royston, and J. D. Pearson,Blood. Cell. Fibrinolysis,3, No. 6, 737–742 (1992).Google Scholar
- 12.R. B. Stricker, D. Wong, D. T. Shiu,et al., Blood,68, No. 2, 1280–1284 (1986).Google Scholar