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Antiarrhythmic properties of a new Suphan-based combined preparation and their possible mechanism of realisation

  • Pharmacology and Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Considerable potentiation of antiarrhythmic and antifibrilation effects of two cardiotonic agents, Suphan and the Na-channel blocker L1, was found in the model experimentsin vivo with early occlusion and reperfusion arrhythmias. Suphan in combination with L1 inhibited the rise of intracellular Ca2+ (by about 70%) in isolated cardiomyocytes incubated under hypoxic conditions.

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Authors and Affiliations

  1. Department of Pharmacology, Kuban Medical Academy, Krasnodar

    A. I. Khankoeva, N. B. Leonidov & P. A. Galenko-Yaroshevskii

  2. Russian State Medical University, Moscow

    A. S. Dukhanin & D. S. Galygo

Authors
  1. A. I. Khankoeva
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  2. A. S. Dukhanin
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  3. N. B. Leonidov
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  4. P. A. Galenko-Yaroshevskii
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  5. D. S. Galygo
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii I Meditsiny, Vol. 125, No. 1, pp. 59–62, January, 1998

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Khankoeva, A.I., Dukhanin, A.S., Leonidov, N.B. et al. Antiarrhythmic properties of a new Suphan-based combined preparation and their possible mechanism of realisation. Bull Exp Biol Med 125, 50–52 (1998). https://doi.org/10.1007/BF02496800

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  • DOI: https://doi.org/10.1007/BF02496800

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