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A study of the mechanism of action of befol on Ca2+ metabolism in cardiomyocytes using a FURA-2 fluorescent probe

  • Pharmacology and Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The dynamics of the Ca-response of cardiomyocytes is studied and the efficiency of befol, verapamil, and amiodarone is compared using various experimental models of stimulation of [Ca2+]i. Befol (1–5 μM) is shown to inhibit the caffeine-and strophanthin G-induced rise of [Ca2+]i. Unlike verapamil and amiodarone, befol exhibits no Ca-blocking activity in modeled K-depolarization. It is concluded that the cardiotropic effect of befol is mediated through its primary action on Na+/Ca2+ exchange in cardiomyocytes, while the cardioplegic effect of verapamil and amiodarone is due to their ability to block the slow Ca2+ inward current.

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Authors and Affiliations

  1. Department of Molecular Pharmacology and Radiobiology, Russian State Medical University, Moscow

    P. V. Sergeev, P. A. Galenko-Yaroshevskii, A. I. Khankoeva & A. S. Dukhanin

  2. Department of Pharmacology, Kuban Medical Academy, Krasnodar

    P. V. Sergeev, P. A. Galenko-Yaroshevskii, A. I. Khankoeva & A. S. Dukhanin

Authors
  1. P. V. Sergeev
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  2. P. A. Galenko-Yaroshevskii
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  3. A. I. Khankoeva
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  4. A. S. Dukhanin
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No 3, pp. 288–291, March, 1996

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Sergeev, P.V., Galenko-Yaroshevskii, P.A., Khankoeva, A.I. et al. A study of the mechanism of action of befol on Ca2+ metabolism in cardiomyocytes using a FURA-2 fluorescent probe. Bull Exp Biol Med 121, 265–267 (1996). https://doi.org/10.1007/BF02446765

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  • DOI: https://doi.org/10.1007/BF02446765

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