Abstract
A 16-year-old girl suffering from intractable temporal lobe epilepsy presented with a pilocytic astrocytoma, which occurred in an area of nodular heterotopia located in the white matter of the temporal lobe. The pilocytic astrocytoma appeared to be covered by an area of gliosis, which contained numerous Rosenthal fibers, while in the lesion the pilocytic astrocytoma occupied a small area. The gliosis eventually became a tumor-like lesion. The while matter around the mass was composed of gliosis with nodular heterotopia. Temporal developmental malformation, which was a basic lesion of the patient, might therefore be a precursor lesion of pilocytic astrocytomas.
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References
Wolf HK, Campos MG, Zentner J, et al (1993) Surgical pathology of temporal lobe epilepsy. Experience with 216 cases. J Neuropathol Exp Neurol 52:499–506
Armstrong DD (1993) The neuropathology of temporal lobe epilepsy. J Neuropathol Exp Neurol 52:433–443
Taylor DC, Falconer MA, Bruton CJ, et al (1971) Focal cortical dysplasia of the cerebral cortex in epilepsy. J Neurol Neurosurg Pscychiatry 34:369–387
Palmini, Andermann F, Olivier A, et al (1991) Focal neuronal migration disorders and intractable partial epilepsy: a study of 30 patients. Ann Neurol 30:741–749
Kaspers BS, Stefan H, Buchfelder M, et al (1999) Temporal lobe microdysgenesis in epilepsy versus control brains. J Neuropathol Exp Neurol 58:22–28
Wolf HK, Wellmer J, Müller MB, et al (1995) Glioneuronal malformative lesions and dysembryoplastic neuroepithelial tumors in patients with chronic pharmacoresistant epilepsies. J Neuropathol Exp Neurol 54:245–254
Li LM, Dubeau F, Andermann F, et al (1997) Periventricular nodular heterotopias and intractable temporal lobe epilepsy: poor outcome after temporal lobe resection. Ann Neurol 41:662–668
Kuzniecky R, Ho SS, Martin R, et al (1999) Temporal lobe developmental malformations and hippocampal sclerosis. Epilepsy surgical outcome. Neurology 52:479–484
Prayson RA, Estes ML, Morris HH (1993) Coexistence of neoplasia and cortical dysplasia in patients presenting with seizures. Epilepsia 34:609–615
Oda M, Arai N, Maehara T, et al (1998) Brain tumors in surgical neuropathology of intractable epilepsies, with special reference to cerebral dysplasias. Brain Tumor Pathol 15:41–51
Yagishita A, Arai N, Maehara T, et al (1997) Focal cortical dysplasia: appearance on MR images. Radiology 203:553–559
McLendon RE, Enterline DS, Tien RD, et al (1998) Tumors of neuroepithelial origin. In: Bigner DD, McLendon RE, Bruner JM (eds) Russell and Rubinstein's pathology of tumors of the nervous system, 6th edn. Arnold, London, pp 307–571
Vuia O (1979) Dysplastic gliosis (spongioblastosis) and the Rosenthal fibers. Virchow Arch (Pathol Anat) 361:1–10
Kawano N (1992) Pleomorphic xanthoastrocytoma: some new observations. Clin Neuropathol 11:323–328
Dmitrovic B, Jadro-Santel D, Zarkovic K (1991) The occurrence of Rosenthal fibres in the brain tissue around meningioma. Neurol Croat 40:181–186
Kreutzberg GW, Blakemore WF, Graeber MB (1997) Cellular pathology of the central nervous system. In: Graham DI, Lantos PL (eds) Greenfield's neuropathology, 6th edn. Arnold, London, pp 85–156
Brantley K, Francel P, Leech R, et al (2000) Astrocytoma arising in a glial hamartoma: correlation with deregulation of p53 gene expression. J Neuropathol Exp Neurol 59:439
Volk EE, Prayson RA (1997) Hamartoma in the setting of chronic epilepsy: a clinicopathologic study of 13 cases. Hum Pathol 28:227–232
Wolf HK, Müller MB, Spänle M, et al (1994) Ganglioglioma: a detailed histopathological and immunohistochemical analysis of 61 cases. Acta Neuropathol 88:166–173
Leung SY, Gwi E, Ng HK, et al (1994) Dysembryoplastic neuroepithelial tumor, a tumor with small neuronal cells resembling oligodendroglioma. Am J Surg Pathol 18:604–614
Ramelli GP, von der Weid N, Remonda L, et al (2000) Pleomorphic xanthoastrocytoma derived from glioneuronal malformation in a child with intractable epilepsy. J Child Neurol 15:270–272
Demaerel P, Droessaert M, Lammens M, et al (1996) Anaplastic (malignant) ganglioglioma arising from heterotopic grey matter nodules. J Neurooncol 30:237–242
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Amagasa, M., Kojima, H., Yuda, F. et al. Pilocytic astrocytoma arising from an area of nudular heterotopia located in the white matter of the temporal lobe: case report. Brain Tumor Pathol 17, 147–151 (2000). https://doi.org/10.1007/BF02484286
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DOI: https://doi.org/10.1007/BF02484286