Skip to main content
SpringerLink
Log in

The effects of high-frequency microstimulation of the cortex on interhemisphere synchronization in the rat motor cortex

  • Published:
Neuroscience and Behavioral Physiology Aims and scope Submit manuscript

Abstract

Studies were carried out on long-term changes in the synchronization of neuronal activity in networks including callosal cells of the opposite hemispheres evoked by higher-frequency microstimulation in the motor cortex of anesthetized rats. The level of synchronization was assessed in terms of the amplitude and width of peaks located symmetrically on, cross-correlograms relative to the coordinate origin. Tetanization predominantly decreased synchronization in a group of initially background-active neurons, while there was a significant number of synchronously firing neurons in a group of cells which became activated. “Supernarrow” peaks appeared in interhemisphere interactions. There was a correlation between the type of modification of “narrow” (<20 msec) and “intermediate” (30–80 msec) peaks and changes in the efficiencies of mono- and polysynaptic connections.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. O. G. Bogdanova, “Long-term post-tetanic changes in the background activity of neurons in both hemispheres,”Zh. Vyssh. Nerv. Deyat.,46, No. 6, 1115–1119 (1996).

    CAS  Google Scholar 

  2. O. G. Bogdanova and I. G. Sil'kis, “Characteristics of back-ground gamma oscillations in neuronal networks including callosal cells,”Zh. Vyssh. Nerv. Deyat.,47, No. 4, 771–776 (1997).

    CAS  Google Scholar 

  3. I. G. Sil'kis, “Simultaneous activation of excitatory and inhibitory inputs as a condition for the induction of homohetero-, and associative long-term depression of excitation,”Zh. Vyssh. Nerv. Deyat.,45, No. 6, 1149–1163 (1995).

    Google Scholar 

  4. I. G. Sil'kis, “Long-term changes in the efficiency of excitatory synaptic transmission in thalamocortical circuits evoked by cortical microstimulation,”Zh. Vyssh. Nerv. Deyat.,45, No. 2, 321–335 (1995).

    Google Scholar 

  5. I. G. Sil'kis, “Long-term changes in the efficiency of inhibitory transmission in thalamocortical neuronal networks evoked by cortical microstimulation,”Zh. Vyssh. Nerv. Deyat.,45, No. 3, 538–550 (1995).

    Google Scholar 

  6. I. G. Sil'kis and O. G. Bogdanova, “The characteristics and possible mechanisms of interhemisphere synchronization in the rat motor cortex,”Ros. Fiziol. Zh. im. I. M. Sechenova, in press (1998).

  7. A. K. Engel, P. Konig, A. K. Kreiter, and W. Singer, “Interhemispheric synchronization of oscillatory neuronal responses in cat visual cortex,”Science,252, No. 5010, 1177–1179 (1991).

    PubMed  CAS  Google Scholar 

  8. G. L. Gerstein and D. H. Perkel, “Mutual temporal relationships among neuron spike trains,”Biophys. J.,12, 453–473 (1972).

    Article  PubMed  CAS  Google Scholar 

  9. M. Matsumura, D.-F. Chen, T. Sawaguchi, K. Kubota, and E. E. Fetz, “Synaptic interactions between primate precentral cortex neurons revealed by spike-triggered averaging of intracellular membrane potentials in vivo,”J. Neurosci.,16, 7757–7767 (1996).

    PubMed  CAS  Google Scholar 

  10. M. H. J. Munk, L. G. Nowak, J. L. Nelson, and J. Buller, “The structural bases of cortical synchronization. II. Effects of cortical lesions,”J. Neurophysiol.,74, 2401–2414 (1995).

    PubMed  CAS  Google Scholar 

  11. J. I. Nelson, P. A. Salin, M. H. J. Munk, M. Arzi, and J. Buller, “Spatial and temporal coherence in corticocortical connections: a cross-correlation study in areas 17 and 18 in the cat,”Visual Neurosci.,9, 21–38 (1992).

    Article  CAS  Google Scholar 

  12. L. C. Nowak, M. H. J. Munk, J. I. Nelson, A. C. James, and J. Buller, “The structural bases of cortical synchronization. I. Three types of interhemispheric coupling,”J. Neurophysiol.,74, 2379–2400 (1995).

    PubMed  CAS  Google Scholar 

  13. W. Singer, “Synchronization of cortical activity and its putative role in information processing and learning,”Ann. Rev. Physiol.,55, 349–374 (1993).

    Article  CAS  Google Scholar 

  14. A. M. Thomson and J. Deuchars, “Temporal and spatial properties of local circuits in neocortex,”Trends Neurosci.,17, 119–126 (1994).

    Article  PubMed  CAS  Google Scholar 

  15. K. Toyama, M. Kimura, and K. Tanaka, “Cross-correlation analysis of interneuronal connectivity in cat visual cortex,”J. Neurophysiol.,46, 191–201 (1981).

    PubMed  CAS  Google Scholar 

  16. E. Vaadia, E. Ahissar, H. Bergman, and Y. Lavner, “Correlated activity of neurons. A neural code for higher brain function?,” in:Neural Cooperativity, Berlin, Heidelberg (1991).

Download references

Author information

Authors and Affiliations

  1. Neurophysiology Laboratory, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 5a Butlerov Street, 117865, Moscow, Russia

    I. G. Sil'kis

Authors
  1. O. G. Bogdanova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. G. Sil'kis
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 84, No. 7, pp. 614–623, July, 1998.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bogdanova, O.G., Sil'kis, I.G. The effects of high-frequency microstimulation of the cortex on interhemisphere synchronization in the rat motor cortex. Neurosci Behav Physiol 29, 515–522 (1999). https://doi.org/10.1007/BF02461143

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02461143

Key Words

Search

Navigation