Abstract
Experiments on anesthetized cats were used to study the activity of motor cortex neurons (field 4γ) in response to separate and simultaneous stimulation of the ventrolateral nucleus of the thalamus and the somatosensory cortex (field 2) of the brain. Long-term potentiation of motor cortex neuron activity in response to simultaneous stimulation of the ventrolateral nucleus and somatosensory cortex arose only in regions receiving corticocortical projections from the stimulation site in the somatosensory cortex of the brain, while regions lacking corticocortical projections from the somatosensory cortex showed no such effect. Experiments demonstrated that the duration of increased motor cortex neuron activity following stimulation of the ventrolateral nucleus of the thalamus and somatosensory cortex was greater than one hour after recording was started. These data led to the conclusion that simultaneous stimulation of corticocortical and thalamocortical afferents can alter the level of neuronal activity in the motor cortex only in regions with convergent sensory inputs from the thalamus and somatosensory cortex of the brain.
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References
H. Asanuma, “The pyramidal tract,” in:The Nervous System, Handbook of Physiology, J. M. Brookhart, V. B. Mountcastle, V. D. Brooks, et al. (Eds.), Amer. Physiol. Soc. (1981), Vol. II, part 1, pp. 703–733.
H. Asanuma, J. Fernandez, M. E. Scheibel, and A. B. Scheibel, “Characteristics of projections from the nucleus ventral lateralis to the motor cortex in the cats. An anatomical and physiological study,”Exp. Brain Res.,20, No. 4, 315–330 (1974).
H. Asanuma and A. Keller, “Neuronal mechanisms of motor learning in mammals,”NeuroReport,2, No. 2, 217–224 (1991).
R. L. Berry, T. J. Teyler, and N. Taizhen, “Induction of LTP in rat primary visual cortex: tetanus parameters,”Brain Res.,481, No. 2, 221–227 (1989).
L. J. Bindman, K. P. S. J. Murphy, and S. J. Pockett, “Post-synaptic control of the induction of long-term changes in efficacy of transmission at neocortical synapses in slices of rat brain,”J. Neurophysiol.,60, No. 3, 1053–1065 (1988).
M. Caria, T. Kaneko, A. Kimura, and H. Asanuma, “Functional organization of the projection from area 2 to area 4 in the cat,”J. Neurophysiol.,77, 3107–3114 (1997).
A. Iriki, C. Pavlidis, A. Keller, and H. Asanuma, “Long-term potentiation in motor cortex,”Science,245, No. 4924, 1385–1387 (1989).
A. Iriki, C. Pavlidis, A. Keller, and H. Asanuma, “Long-term potentiation of thalamic input to the motor cortex induced by coactivation of thalamo-cortical and cortico-cortical afferents,”J. Neurophysiol.,65, No. 6, 1435–1441 (1991).
T. Keneko, M. A. Caria, and H. Asanuma, “Information processing within the motor cortex. Responses of morphologically identified motor cortical cells to stimulation of the somatosensory cortex,”J. Comp. Neurol.,345, No. 1, 161–171 (1994).
A. Keller, A. Iriki, and H. Asanuma, “Identification of neurons producing long-term potentiation in the cat motor cortex. Intracellular recordings and labeling,”J. Comp. Neurol.,300, No. 1, 47–60 (1990).
A. Keller, E. Majashita, and H. Asanuma, “Minimal stimulus parameters and the effects of hyperpolarization on the induction of long-term potentiation in the cat motor cortex,”Exp. Brain Res.,87, No. 2, 292–302 (1991).
A. Kimura, M. A. Caria, F. Melus, and H. Asanuma, “Long-term potentiation within the cat motor cortex,”NeuroReport,5, No. 17, 2372–2376 (1994).
A. Kirkwood and M. F. Bear, “Hebbian synapses in visual cortex,”J. Neuroscience,14, No. 3, 1634–1645 (1994).
H. Kluver and E. A. Barrera, “A method for the combined staining of cells and fibers in the nervous system,”J. Neuropath. Exp. Neurol.,12, 400–403 (1953).
Y. Komatsu, K. Fujii, J. Maeda, et al., “Long-term potentiation of synaptic transmission in kitten visual cortex,”J. Neurophysiol.,59, No. 1, 124–141 (1988).
E. Kosar, R. S. Waters, N. Tsukuhara, and H. Asanuma, “Anatomical and physiological properties of the projection from the sensory cortex to the motor cortex in normal cats: the difference between cortico-cortical and thalamo-cortical projections,”Brain Res.,345, No. 1, 68–78 (1985).
A. Kossel, T. Bonhoeffer, and J. Bolz, “Non-Hebbian synapses in rat visual cortex,”J. NeuroReport,1, No. 2, 115–118 (1990).
L. L. Porter and K. J. Sakamoto, “Organization and synaptic relationships of the projection from the primary sensory to the primary motor cortex in the cat,”J. Comp. Neurol.,271, No. 3, 387–396 (1988).
T. Sakamoto, L. L. Porter, and H. Asanuma, “Long-lasting potentiation of synaptic potentials in the motor cortex produced by stimulation of the sensory cortex in the cat: a basis for motor learning,”Brain Res.,413, No. 2, 360–364 (1987).
P. L. Strick, “Light microscopic analysis of the cortical projection of the thalamic ventrolateral nucleus in the cat,”Brain Res.,55, No. 1, 1–24 (1973).
R. S. Waters, O. Favorov, and H. Asanuma, “Physiological properties and pattern of projection of cortico-cortical connections from the anterior bank of the ansate sulcus to the motor cortex area 4, in the cat,”Exp. Brain Res.,46, No. 3, 403–412 (1982).
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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 84, No. 5–6, pp. 460–468, May–June, 1998.
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Kimura, A., Grigor'yan, R. & Asanuma, H. Long-term increases in neuronal activity in the motor cortex evoked by simultaneous stimulation of the thalamus and somatosensory cortex in cats. Neurosci Behav Physiol 29, 475–481 (1999). https://doi.org/10.1007/BF02461088
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DOI: https://doi.org/10.1007/BF02461088