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Role of cell signaling systems in the regulation of Ca2+-activated potassium channels in erythrocytes

  • Biophysics and Biochemistry
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effect of inhibitors of calmodulin and protein kinase C, complex [AlF4]−, and potassium channel blockers on the parameters of calcium-induced hyperpolarization in human erythrocytes is studied by recording proton distribution between the cytoplasm and incubation medium in the presence of a protonophore. It is shown that the calmodulin inhibitor dis-C3-5, the protein kinase C inhibitor staurosporine, and the blocker of highconductance calcium-activated potassium channels considerably suppress the calciuminduced hyperpolarization in erythrocytes. High concentration of [AlF4]− in the incubation medium inhibits hyperpolarization.

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Authors and Affiliations

  1. Siberian State Medical University, Tomsk

    I. V. Petrova, E. A. Stepovaya, M. V. Kolosova, I. B. Sokolova, V. V. Novitskii, M. B. Baskalov & M. A. Medvedev

  2. Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Siberia

    I. V. Petrova, E. A. Stepovaya, M. V. Kolosova, I. B. Sokolova, V. V. Novitskii, M. B. Baskalov & M. A. Medvedev

Authors
  1. I. V. Petrova
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  2. E. A. Stepovaya
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  3. M. V. Kolosova
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  4. I. B. Sokolova
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  5. V. V. Novitskii
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  6. M. B. Baskalov
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  7. M. A. Medvedev
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 6, pp. 653–655, June, 1997

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Petrova, I.V., Stepovaya, E.A., Kolosova, M.V. et al. Role of cell signaling systems in the regulation of Ca2+-activated potassium channels in erythrocytes. Bull Exp Biol Med 123, 568–570 (1997). https://doi.org/10.1007/BF02458079

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  • DOI: https://doi.org/10.1007/BF02458079

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