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Role of Potassium Ions in Regulation of Calcium-Activated Chloride Channels

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
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Abstract

Using the patch-clamp method in the whole cell configuration, it was shown that external potassium ions play an important role in the regulation of calcium-activated chloride channels (CaCCs). A clear dependence of the conductivity of the СаССs on the external potassium concentration was shown. The effect of external potassium in the range 0–15 mM on the conductivity of chloride channels was significantly greater than the effect it had on other ionic currents (sodium or potassium). There is reason to believe that these changes in the conductivity of CaCCs may contribute to the development of pathophysiological processes such as hypokalemia or hyperkalemia.

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Funding

This study was supported by the Russian Science Foundation (project no. 19-13-00378) and State assignment for 2019–2020 (topic no. 0090-2019-0005).

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Authors and Affiliations

  1. Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia

    V. L. Zamoyski, E. V. Bovina,  S. O. Bachurin & V. V. Grigoriev

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  1. V. L. Zamoyski
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  2. E. V. Bovina
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  3. S. O. Bachurin
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  4. V. V. Grigoriev
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Corresponding author

Correspondence to V. L. Zamoyski.

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The authors declare that they have no conflict of interests. This article does not contain any studies involving animals or human participants performed by any of the authors.

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Translated by M. Batrukova

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Zamoyski, V.L., Bovina, E.V., Bachurin, S.O. et al. Role of Potassium Ions in Regulation of Calcium-Activated Chloride Channels. Dokl Biochem Biophys 500, 321–323 (2021). https://doi.org/10.1134/S1607672921050215

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  • DOI: https://doi.org/10.1134/S1607672921050215

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