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Immunocytochemical study of the localization of scavenger receptor in human aortic smooth-muscle cells

  • Morphology and Pathomorphology
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Abstract

Scavenger receptor was soughtin situ in human aortic smooth-muscle cells and in a primary culture of intact human aortic intima using antibodies to scavenger receptor. For identification of smooth-muscle cells, double staining making use of antibodies to murine α-actin was used. The presence of scavenger receptor in smooth-muscle cells of the intima and media of human aorta was demonstrated on aortic slices. In cultured smooth-muscle cells from normal human aortic intima scavenger receptor was distributed over the entire surface of the cell membrane, forming clusters in some places. These results suggest that human aortic smooth-muscle cells express scavenger receptor.

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Authors and Affiliations

  1. Institute of Experimental Cardiology, Cardiology Research Center, Russian Academy of Medical Sciences, Moscow

    V. L. Nazarova, E. R. Andreeva, V. V. Tertov, B. S. Gel'dieva & A. N. Orekhov

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  1. V. L. Nazarova
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  2. E. R. Andreeva
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  3. V. V. Tertov
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  4. B. S. Gel'dieva
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  5. A. N. Orekhov
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, No 8, pp. 195–198, August, 1995

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Nazarova, V.L., Andreeva, E.R., Tertov, V.V. et al. Immunocytochemical study of the localization of scavenger receptor in human aortic smooth-muscle cells. Bull Exp Biol Med 120, 839–842 (1995). https://doi.org/10.1007/BF02445969

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  • DOI: https://doi.org/10.1007/BF02445969

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