Abstract
A long-term increase in the amplitude and quantum composition of potentials from the end-plate was observed in isolated rat diaphragm with inhibited acetylcholinesterase during washing from acetylcholine. The amplitude and temporal parameters of the miniature potentials did not change, while their frequency decreased in the presence of acetylcholine and continuel to fall during 1–2 h of washing. The addition of ouabain restored the frequency of these potentials; in the presence of ouabain acetylcholine had no effect on this parameter. Hyperpolarization of the extrasynpatic area of muscle fibers (2–3 mV) caused by acetylcholine is preserved during washing. Hyperpolarization was also observed against the background of tolbutamide but not in the presence of oubain and heparin.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 5, pp. 531–534, May, 1997
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Kubasov, I.V., Krivoi, I.I. & Lopatina, E.V. Role of Na+/K+ ATPase in presynaptic afteraction of exogenous acetylcholine in rat diaphragm. Bull Exp Biol Med 123, 462–464 (1997). https://doi.org/10.1007/BF02445319
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DOI: https://doi.org/10.1007/BF02445319