Abstract
Paraoxon is shown to reduce the density of M-choline receptors in the cortex of rat brain. Inhibition of3H-QNB is noncompetitive and reversible in nature. Sulfhydryl reagents do not affect this process. The mechanism of action of PO is thought to include direct effects on brain muscarine receptors.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, No 7, pp. 51–53, July, 1994
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Golovko, A.I., Sofronov, G.A., Kurganova, T.A. et al. Effect of paraoxon and sulfhydryl reagents on3H-quinuclidinol benzoate and3H-methylscopolamine with synaptic membranes of rat brain. Bull Exp Biol Med 118, 734–736 (1994). https://doi.org/10.1007/BF02444372
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DOI: https://doi.org/10.1007/BF02444372