Abstract
A kinetic model describing the dynamics of synaptic “discharge” taking into account the kinetics of the injection of the neurotransmitter into the synaptic cleft, the pH-dependence of the catalytic activity of the enzyme, and diffusion withdrawal of protons is proposed. The model provides a physicochemical explanation for a number of important physiological phenomena, such as the neuromuscular paralysis, the molecular mechanism of neurological memory, and the effect of some neurotoxins and drugs.
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This work was supported by the Russian Science Foundation (project no. 18-13-00030).
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Translated by M. Batrukova
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Varfolomeev, S.D., Bykov, V.I. & Tsybenova, S.B. Kinetics of Chemical Processes in the Human Brain. Proton Blockade of Acetylcholinesterase and pH-Impulse in the Mechanism of Functioning of the Cholinergic Synapse. Dokl Biochem Biophys 491, 85–88 (2020). https://doi.org/10.1134/S1607672920020155
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DOI: https://doi.org/10.1134/S1607672920020155