Skip to main content

Advertisement

SpringerLink
Log in

Hemolytic anemia provoked by recombinant alpha-interferon

  • Case Reports
  • Published:
Journal of Gastroenterology Aims and scope Submit manuscript

Abstract

A 30-year-old female with chronic hepatitis C treated with recombinant alpha-interferon developed serious hemolytic anemia after receiving 10 million units a day for 4 weeks. The results of Coombs' tests were negative before and after interferon therapy. The hemolytic anemia gradually improved after the with-drawal of recombinant alpha-interferon and the administration of methyl-prednisolone. The clinical course suggested that the recombinant alpha-interferon had provoked the hemolytic anemia.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Isaccs A, Lindenmann J. Virus interference. I. The interferons. Proc R Soc Lond [Biol] 1957;147:258–267.

    Google Scholar 

  2. Hoofnagle JH, Mullen KD, Jones DB, et al. Treatment of chronic non-A, non-B hepatitis with recombinant human alpha interferon. N Engl J Med 1986;315:1575–1578.

    CAS  PubMed  Google Scholar 

  3. Fentiman IS, Thomas BS, Balkwill FR, et al. Primary hypothyroidism associated with interferon therapy of breast cancer. Lancet 1985;I:1166.

    Google Scholar 

  4. Burman P, Karlsson FA, Oberg K, et al. Autoimmune thyroid disease in interferon-treated patients. Lancet 1985;II:100–101.

    Google Scholar 

  5. Bevan PC. Interferon-induced parotitis and epididymitis. Lancet 1985;II:561.

    Google Scholar 

  6. McLaughlin P, Talpaz M, Quesada JR, et al. Immune thrombocytopenia following α-interferon therapy in patients with cancer. JAMA 1985;254:1353–1354.

    Article  CAS  PubMed  Google Scholar 

  7. Ronnblom LE, Alm GV, Oberg KE. Autoimmunity after alpha-interferon therapy for malignant carcinoid tumors. Ann Intern Med 1991;115:178–183.

    CAS  PubMed  Google Scholar 

  8. Renault PF, Hoofnagle JH. Side effects of alpha interferon. Semin Liver Dis 1989;9:273–277.

    CAS  PubMed  Google Scholar 

  9. Akard LP, Hoffman R, Elias L, et al. Alpha-interferon and immune hemolytic anemia. Ann Intern Med 1986;105:306.

    CAS  PubMed  Google Scholar 

  10. Fornaciari G, Bassi C, Beltrami M. et al. Hemolytic anemia secondary to interferon treatment for chronic B hepatitis. J Clin Gastroenterol 1991;13:596–597.

    CAS  PubMed  Google Scholar 

  11. Schattner A, Duggan D, Naparstek Y, et al. Effects of interferon-α on the expression of a lupus idiotype in normal humans. Clin Immunol Immunopathol 1986;38:327–336.

    Article  CAS  PubMed  Google Scholar 

  12. Revel M, Chebath J. Interferon-activated genes. Trends Biol Sci 1986;11:166–170.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The First Department of Internal Medicine, Mie University School of Medicine, 2-174 Edobashi, 514, Tsu, Mie, Japan

    Koujirou Takase, Takeshi Nakano, Minoru Hamada, Katsuya Shiraki, Youhei Oohashi & Takayuki Kihira

  2. Department of Laboratory Medicine, Mie University School of Medicine, 2-174 Edobashi, 514, Tsu, Mie, Japan

    Yukihiko Tameda

Authors
  1. Koujirou Takase
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Takeshi Nakano
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Minoru Hamada
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Katsuya Shiraki
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Youhei Oohashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Takayuki Kihira
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yukihiko Tameda
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Takase, K., Nakano, T., Hamada, M. et al. Hemolytic anemia provoked by recombinant alpha-interferon. J Gastroenterol 30, 795–797 (1995). https://doi.org/10.1007/BF02349651

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02349651

Key words

Search

Navigation