Skip to main content
SpringerLink
Log in

An overview of the applications of capillary electrophoresis to the analysis of pharmaceutical raw materials and excipients

  • Review
  • Published:
Chromatographia Aims and scope Submit manuscript

Summary

The use of capillary electrophoresis for the separation and quantitation of a range of pharmaceutical raw materials and excipients is reviewed. Capillary electrophoresis is shown to be a useful and versatile technique for a large number of applications. Features of the various methods include simplicity, detection of poor chromatophore species by extensive use of indirect UV detection or direct absorbance at low wavelengths, minimal operating costs and generation of high quality retrievable raw data. Specific novel examples described include separations of lactose, flavouring agents, inorganic salts, lecithin constituents, a range of organic acids, benzylalkonium chloride components, sodium lauryl sulphate, and the quality of input water. It is concluded that the versatility of CE will ensure that it is increasingly used in the analysis of pharmaceutical raw materials and excipients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. P. York, Pharm. Tech. Europe, June, 17 (1994).

  2. K. D. Altria KD (Ed.) “Capillary electrophoresis guidebook, Principles, operation, and applications”, Humana Press, Totowa, NJ, 1995.

    Google Scholar 

  3. H. Nishi, S. Terabe, Electrophoresis11, 691 (1990).

    Google Scholar 

  4. K. D. Altria, M. Kersey, LG-CG Int.8, 201 (1995).

    Google Scholar 

  5. K. D. Altria, J. S. Howells, J. Chromatogr.696, 341 (1995).

    Google Scholar 

  6. P. Oefner, C. Chiesa, G. Bonn, C. Horvath, J. Capillary Electrophoresis1, 5 (1994).

    Google Scholar 

  7. A. Klockow, A. Paulus, V. Figueiredo, R. Amado, H. M. Widmer, J. Chromatogr.680, 187 (1994).

    Google Scholar 

  8. S. Hoffstetter-Kuhn, A. Paulus, E. Gassman, H. M. Widmer, Anal. Chem.63, 1541 (1992).

    Google Scholar 

  9. A. E. Vorndran, P. J. Oefner, H. Scherz, G. K. Bonn, Chromatographia33, 163 (1992).

    Google Scholar 

  10. A. Nardi, S. Fanali, F. Foret, Electrophoresis11, 734 (1990).

    Google Scholar 

  11. S. G. Penn, R. W. Chiu, C. A. Monnig, J. Chromatogr.680, 233 (1994).

    Google Scholar 

  12. N. W. Smith, M. B. Evans, J. Pharm. Biomed. Anal.12, 579 (1994).

    Google Scholar 

  13. K. D. Altria, M. M. Rogan, in “Introduction to Capillary Electrophoresis of pharmaceuticals”, published by Beckman Instruments, Fullerton, California, US, 1994, p. 1–55.

    Google Scholar 

  14. K. D. Altria, P. Frake, I. Gill, T. A. Hadgett, M. A. Kelly, D. R. Rudd, J. Pharm. Biomed. Anal.13, 951 (1995).

    Google Scholar 

  15. K. D. Altria, T. A. Hadgett, J. Chromatogr. in press

  16. S. M. Burkinshaw, D. Hinks, D. M. Lewis, J. Chromatogr.640, 413 (1993).

    Google Scholar 

  17. D. Hinks, D. M. Lewis, Chromatography and Analysis Aug/Sept. 9 (1993).

  18. S. Suzuki, M. Shirao, M. Aizawa, H. Nakazawa, K. Sasa, H. Sasagawa, J. Chromatogr.680, 541 (1994).

    Google Scholar 

  19. K. P. Evans, G. L. Beamont, J. Chromatogr.636, 153 (1993).

    Google Scholar 

  20. K. N. Tapley, J. Chromatogr.706, 555 (1995).

    Google Scholar 

  21. F. B. Erim, X. Xu, J. C. Kraak, J. Chromatogr.694, 471 (1995).

    Google Scholar 

  22. G. Gutnikov, W. Beck, H. Engelhardt, J. Microl. Sepn.6, 565 (1994).

    Google Scholar 

  23. R.-A. Assad, P. Gareil J. Chromatogr.708, 339 (1995).

    Google Scholar 

  24. C. O. Thompson, V. G. Trennery, B. Kemmery J. Chromatogr.694, 507 (1995).

    Google Scholar 

  25. K. D. Altria, D. M. Goodall, M. M. Rogan, Chromatographia38, 637 (1994).

    Google Scholar 

  26. J. M. Jordan, R. L. Moese, R. Johnson-Watts, D. E. Burton, J. Chromatogr.671, 445 (1994).

    Google Scholar 

  27. J. B. Nair, C. G. Izzo, J. Chromatogr.640, 445 (1993).

    Google Scholar 

  28. S. D. Filbey, K. D. Altria, J. Capillary Electrophoresis1, 190 (1994).

    Google Scholar 

  29. K. D. Altria, T. Wood, R. Kitscha, A. Roberts-McIntosh, J. Pharm. Biomed. Anal.13, 33 (1995).

    Google Scholar 

  30. K. D. Altria, N. G. Clayton, R. C. Harden, M. Hart, J. Hevizi, J. Makwana, M. J. Portsmouth, Chromatographia40, 47 (1995).

    Google Scholar 

  31. H. Kajiwara, A. Sato, S. Kaneko, Biosci. Biotech. Biochem.57, 1010 (1993).

    Google Scholar 

  32. J. Morawski, P. Alden, A. Sims, J. Chromatogr.640, 359 (1993).

    Google Scholar 

  33. E. Ingvardsen, S. Michaelsen, H. Sorensen, JAOCS,71, 183 (1994).

    Google Scholar 

  34. M. Shirao, R. Furuta, S. Suzuki, H. Nakazawa, S. Fujita, T. Maruyama, J. Chromatogr.680, 247 (1994).

    Google Scholar 

  35. R. C. Chadwick, J. C. Hsieh, Anal. Chem.,63, 2377 (1991).

    Google Scholar 

  36. C. L. Ng, H. K. Lee, S. F. Y. Li, J. Chromatogr. Sci.30, 167 (1992).

    Google Scholar 

  37. C. P. Ong, C. L. Ng, H. K. Lee, S. F. Y. Li, J. Chromatogr.686, 319 (1994).

    Google Scholar 

  38. B. Chankvetadze, G. Endresz, G. Blaschke, J. Chromatogr.700, 43 (1995).

    Google Scholar 

  39. T. L. Bereuter, LC-GC Int.7, 78 (1994).

    Google Scholar 

  40. S. Fanali, P. Bocek, Electrophoresis11, 757 (1990).

    Google Scholar 

  41. K. D. Altria, P. Bocek, Electrophoresis11, 757 (1990).

    Google Scholar 

  42. M. W. F. Nielen, J. Chromatogr.588, 321 (1991).

    Google Scholar 

  43. P. E. Jackson, P. R. Haddad, J. Chromatogr.640, 481 (1993).

    Google Scholar 

  44. G. Bondoux, P. Jandik, W. R. Jones, J. Chromatogr.602, 79 (1992).

    Google Scholar 

  45. E. M. Cohen, R. G. Bell, Pharm. Form.20, 7870 (1994).

    Google Scholar 

  46. K. D. Altria, H. Fabre, Chromatographia40, 313 (1995).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Glaxo-Wellcome R&D, Park Road, SG12 ODP, Ware, Herts, UK

    K. D. Altria & J. Elgey

  2. Glaxo-Wellcome R&D, Stevenage, Herts

    P. Lockwood & D. Moore

Authors
  1. K. D. Altria
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Elgey
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. Lockwood
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D. Moore
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Altria, K.D., Elgey, J., Lockwood, P. et al. An overview of the applications of capillary electrophoresis to the analysis of pharmaceutical raw materials and excipients. Chromatographia 42, 332–342 (1996). https://doi.org/10.1007/BF02290320

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02290320

Key Words

Search

Navigation