Summary
The TLC behaviour of N-phenyl-1,2,4-triazoles and their derivatives on silica gel plates has been studied using simple solvents. Isomers were very well distinguished, resulting from different activities due to hydrogen bonding. A mixture of seven compounds has been resolved with diethylether-n-butylamine-pyridine (91.4:7.7:0.9).
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References
J. F. Fredrick, Phiton (Buenos-Aires),17, 147 (1961), C.A.57, 3730 d (1962).
L. C. Mitchell, J. Assoc. Offic. Agr. Chemists,44, 643 (1961).
H. T. Gordon, W. W. Thornburg, L. N. Werum, J. Chromatogr.9, 44 (1962).
F. Schindler, F. Kuffner, Monatsh. Chem.94, 252 (1963).
A. Cee, M. Adamek, Sb. Ved. Praci, Vysoka Skola Chem. Technol., Pardubice,17, 5 (1968), C.A. 71, 56483t (1969).
H.J. Petrowitz, Chimia19, 426 (1965).
L. I. Bagal, M. S. Pevzner, N. I. Sheludyakova, V. M. Kerusov, Khim. geterotsikl. Soedin6, 265 (1970), C.A. 72, 111384j (1970).
S. Kubota, M. Uda, M. Ohtsuka, Chem. Pharm. Bull.19, 2331 (1971).
N. J. Cusack, G. Shaw, G. J. Litchfield, J. Chem. Soc. C, 1501 (1971)
R. F. Brookes, L. G. Copping, Pestic. Sci.6, 665 (1975).
G. G. Hawn, P. A. Diehl, C. P. Talley, J. Chromatogr. Sci.19, 567 (1981).
D. P. Lopes, J. A. Galloway, J. Chromatogr. Sci.20, 533 (1982).
W. R. Gibson, E.E. Swanson, D. B. Myers, J. Am. Pharm. Assoc.47, 778 (1958).
G. Pellizzari, C. Massa, J. Chem. Soc.80, 488 (1901).
R. A. Henry, W. G. Finnegan, J. Am. Chem. Soc.76, 290 (1954).
C. F. H. Allen, A. Bell, Organic Syntheses26, 11 (1946).
E. G. Kovalev, I. Y. Postovskii, Khim. geterotsikl. Soedin.4, 740 (1968); C.A. 70, 37729 (1969).
C. F. Kröger, R. Miethchen, Z. Chem.9, 378 (1969).
C. Ainsworth, N. R. Easton, M. Livezey, D. E. Morrison, W. R. Gibson, J. Med. Pharm. Chem.5, 383 (1962).
E. Stahl, Thin-Layer Chromatography, A laboratory Handbook, Springer-Verlag, Berlin 1969.
G. C. Pinentel, A. L. McClellan, The Hydrogen Bond, Freeman, San Francisco, Calif., 1960.
S. Hara, J. Chromatogr.137, 41 (1977).
S. Hara, Y. Fujii, M. Hirasawa, S. Miyamoto, J. Chromatogr.149, 143 (1978).
E. Soczewinski, Anal. Chem.41, 179 (1969).
L. R. Snyder, Anal. Chem.46, 1384 (1974).
L. M. Pires, A. N. Roseira, J. Chromatogr.56, 59 (1971).
R. L. Munier, A. M. Drapier,Chromatographia10, 226 (1977).
I. B. Mazheyka, G. Cipens, S. Hillers, Khim. geterotsikl. Soedin.,5, 776 (1966), C.A. 66, 104601a (1967).
K. A. Jensen, A. Friediger, Kgl. Danske Videnskab. Selskab, Math.-fys. Medd. 20, No. 20, 1 (1943), C.A. 39, 2068 (1945).
M. Roche, L. Pujol, Bull. Soc., Chim. 1097 (1969).
P. Goldstein, J. Ladell, G. Abowitz, Acta Cristallogr. Sect. B25, 135 (1969).
H. Saito, Y. Tanaka, S. Nagata, J. Am. Chem. Soc.95, 324 (1973).
M. R. Atkinson, J. B. Polya, J. Chem. Soc. 3319 (1954).
A. Bernardini, P. Viallefont, M. Gelize-Duvigneau, H. Sauvaitre, J. Mol. Structure,34, 245 (1976).
M. Witanowski, L. Stefaniak, H. Januszewski, Z. Grabowski, Tetrahedron,28, 637 (1972).
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Thomas, J. Thin-layer chromatography of 1,2,4-triazoles on silica gel. Chromatographia 18, 149–152 (1984). https://doi.org/10.1007/BF02258772
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DOI: https://doi.org/10.1007/BF02258772