Summary
It was found experimentally that the potential for routine, rapid high-efficiency separations by alternate column, recycle, reversed-phase chromatography is limited by the increase of capacity factors with pressure.
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van der Wal, S. A limit to alternate column recycle chromatography. Chromatographia 22, 81–87 (1986). https://doi.org/10.1007/BF02257304
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DOI: https://doi.org/10.1007/BF02257304