Skip to main content
SpringerLink
Log in

Increasing Efficiency of the Separation of Substance Mixtures by Methods of Liquid–Liquid Chromatography

  • REVIEWS
  • Published:
Journal of Analytical Chemistry Aims and scope Submit manuscript

Abstract

The article is devoted to a brief review of liquid–liquid chromatography methods, such as cyclic chromatography with a discrete motion of the mobile phase and the recirculating, countercurrent, recirculating countercurrent, eluent extrusion, and stationary versions of chromatography. Methods for the preparative separation and isolation of preconcentrated fractions of target components from mixtures are also considered, as well as issues of instrument design of liquid–liquid chromatography processes. The works in the mathematical simulation of separation processes by liquid–liquid chromatography, carried out at the Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, are considered in more detail. Methods of liquid–liquid chromatography can significantly increase the efficiency and productivity of separation processes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.
Fig. 5.
Fig. 6.
Fig. 7.
Fig. 8.
Fig. 9.
Fig. 10.

Similar content being viewed by others

REFERENCES

  1. Maryutina, T.A., Spivakov, B.Ya., Shpigun, L.K., Pavlenko, I.V., and Zolotov, Yu.A., Zh. Anal. Khim., 1990, vol. 45, no. 4, p. 665.

    CAS  Google Scholar 

  2. Chmutova, M.K., Maryutina, T.A., Spivakov, B.Ya., and Myasoedov, B.F., Radiokhimiya, 1992, no. 6, p. 56.

  3. Fedotov, P.S., Maryutina, T.A., Pichugin, A.A., and Spivakov, B.Ya., Zh. Neorg. Khim., 1993, vol. 38, no. 11, p. 1878.

    CAS  Google Scholar 

  4. Maryutina, T.A., Fedotov, P.S., and Spivakov, B.Ya., J. Anal. Chem., 1997, vol. 52, p. 1138.

    Google Scholar 

  5. Fedotov, P.S., Maryutina, T.A., Grebneva, O.N., Kuz’min, N.M., and Spivakov, B.Ya., J. Anal. Chem., 1997, vol. 52, p. 1034.

    CAS  Google Scholar 

  6. Spivakov, B.Ya., Maryutina, T.A., Fedotov, P.S., Ignatova, S.N., Katasonova, O.N., Dahmen, J., and Wennrich, R., J. Anal. Chem., 2002, vol. 57, p. 928.

    Article  CAS  Google Scholar 

  7. Ito, Y. and Bowman, R.L., J. Chromatogr. Sci., 1973, vol. 11, p. 284.

    Article  PubMed  CAS  Google Scholar 

  8. Zolotov, Yu.A., Spivakov, B.Ya., Maryutina, T.A., Bashlov, V.L., and Pavlenko, I.V., Fresenius’ Z. Anal. Chem., 1989, vol. 335, no. 8, p. 938.

    Article  CAS  Google Scholar 

  9. Conway, W.D., Countercurrent Chromatography: Apparatus, Theory and Applications, New York: VCH, 1990.

    Google Scholar 

  10. Maryutina, T.A., Spivakov, B.Ya., and Tschopel, P., Fresenius’ J. Anal. Chem., 1996, vol. 356, p. 430.

    CAS  Google Scholar 

  11. Countercurrent Chromatography, Chromatographic Science Series, vol. 82, Menet, J.M. and Thiebaut, D., Eds., New York: Marcel Dekker, 1999.

    Google Scholar 

  12. Ignatova, S.N., Maryutina, T.A., Spivakov, B.Ya., and Karandashev, V.K., Fresenius’ J. Anal. Chem., 2001, vol. 370, p. 1109.

    Article  CAS  Google Scholar 

  13. Fedotov, P.S., J. Liq. Chromatogr. Relat. Technol., 2002, vol. 25, nos. 13–15, p. 2065.

    Article  CAS  Google Scholar 

  14. Ito, Y., J. Chromatogr. A, 2005, vol. 1065, p. 145.

    Article  PubMed  CAS  Google Scholar 

  15. Friesen, J.B. and Pauli, G.F., Anal. Chem., 2007, vol. 79, p. 2320.

    Article  PubMed  CAS  Google Scholar 

  16. Conway, W.D., J. Chromatogr. A, 2011, vol. 1218, p. 6015.

    Article  PubMed  CAS  Google Scholar 

  17. Hopmann, E. and Minceva, M., J. Chromatogr. A, 2012, vol. 1229, p. 140.

    Article  PubMed  CAS  Google Scholar 

  18. Hopmann, E., Goll, J., and Minceva, M., Chem. Eng. Technol., 2012, vol. 35, p. 72.

    Article  CAS  Google Scholar 

  19. Ignatova, S. and Sutherland, I., J. Chromatogr. A, 2015, vol. 1425, p. 1.

    Article  PubMed  CAS  Google Scholar 

  20. Friesen, J.B., McAlpine, J.B., Chen, S.-N., and Pauli, G.F., J. Chromatogr. A, 2017, vol. 1520, p. 1.

    Article  PubMed  Google Scholar 

  21. Bezold, F. and Minceva, M., J. Chromatogr. A, 2019, vol. 1587, p. 166.

    Article  PubMed  CAS  Google Scholar 

  22. Kostanyan, A.E., Theor. Found. Chem. Eng., 2006, vol. 40, p. 587.

    Article  CAS  Google Scholar 

  23. Kostanian, A.E., J. Chromatogr. A, 2002, vol. 973, p. 39.

    Article  PubMed  CAS  Google Scholar 

  24. Kostanian, A.E., Berthod, A., Ignatova, S.N., Maryutina, T.A., Spivakov, B.Ya., and Sutherland, I.A., J. Chromatogr. A, 2004, vol. 1040, p. 63.

    Article  PubMed  CAS  Google Scholar 

  25. Kostanyan, A.E., J. Chromatogr. A, 2008, vol. 1211, p. 55.

    Article  PubMed  CAS  Google Scholar 

  26. Kostanyan, A.E. and Voshkin, A.A., Theor. Found. Chem. Eng., 2011, vol. 45, p. 68.

    Article  CAS  Google Scholar 

  27. Belter, P.A. and Speaker, S.M., Ind. Eng. Chem. Process Des. Dev., 1967, vol. 6, p. 36.

    Article  CAS  Google Scholar 

  28. Gerster, J.A. and Scull, H.M., AIChE J., 1970, vol. 16, p. 108.

    Article  CAS  Google Scholar 

  29. Konobeev, B.I., Arutyunyan, G.R., and Nazarov, P.S., Teor. Osnovy Khim. Tekhnol., 1977, vol. 11, no. 4, p. 491.

    Google Scholar 

  30. Konobeev, B.I., Arutyunyan, G.R., and Malyusov, V.A., Teor. Osnovy Khim. Tekhnol., 1979, vol. 13, no. 4, p. 499.

    CAS  Google Scholar 

  31. Koltunova, L.N., Teor. Osnovy Khim. Tekhnol., 1980, vol. 14, no. 5, p. 643.

    CAS  Google Scholar 

  32. Kostanyan, A.E., Belova, V.V., and Kholkin, A.I., J. Chromatogr. A, 2007, vol. 1151, nos. 1–2, p. 142.

    Article  PubMed  CAS  Google Scholar 

  33. Kostanyan, A.E. and Voshkin, A.A., J. Chromatogr. A, 2007, vol. 1151, nos. 1–2, p. 126.

    Article  CAS  Google Scholar 

  34. Alders, L. Liquid–Liquid: Theory and Laboratory Experiments, Amsterdam: Elsevier, 1955.

    Google Scholar 

  35. Craig, L.C., J. Biol. Chem., 1944, vol. 155 P, p. 519.

  36. Berthod, A., Billardello, B., and Geoffroy, S., Analysis, 1999, vol. 27, p. 750.

    CAS  Google Scholar 

  37. Marchal, L., Intes, O., Foucault, A., Legrand, J., Nuzillard, J.-M., and Renault, J.-H., J. Chromatogr. A, 2003, vol. 1005, p. 51.

    Article  PubMed  CAS  Google Scholar 

  38. Zhao, C.-X. and He, C.-H., J. Chromatogr. A, 2007, vol. 1146, p. 186.

    Article  PubMed  CAS  Google Scholar 

  39. Peng, A., Hewitson, P., Ye, H., Zu, L., Garrard, I., Sutherland, I., Chen, L., and Ignatova, S., J. Chromatogr. A, 2016, vol. 1476, p. 19.

    Article  PubMed  CAS  Google Scholar 

  40. Kostanyan, A.E., J. Chromatogr. A, 2012, vol. 1254, p. 71.

    Article  PubMed  CAS  Google Scholar 

  41. Kostanyan, A.E., J. Chromatogr. A, 2016, vol. 1471, p. 94.

    Article  PubMed  CAS  Google Scholar 

  42. Porter, R.S. and Johnson, J.F., Nature, 1959, vol. 183, p. 391.

    Article  CAS  Google Scholar 

  43. Seidel-Morgenstern, A. and Guiochon, G., AIChE J., 1993, vol. 39, p. 809.

    Article  CAS  Google Scholar 

  44. Dingenen, J., J. Chromatogr. A, 1994, vol. 666, p. 627.

    Article  CAS  Google Scholar 

  45. Chartor, F., Bailly, M., and Guiochon, G., J. Chromatogr. A, 1994, vol. 687, p. 13.

    Article  Google Scholar 

  46. Heuer, C., Seidel-Morgenstern, A., and Hugo, P., Chem. Eng. Sci., 1995, vol. 50, p. 1115.

    Article  CAS  Google Scholar 

  47. Du, Q.Z., Ke, C.Q., and Ito, Y., J. Liq. Chromatogr. Relat. Technol., 1998, vol. 21, p. 157.

    Article  CAS  Google Scholar 

  48. Oka, H., Iwaya, M., Harada, K., Suzuki, M., and Ito, Y., Anal. Chem., 2000, vol. 72, p. 1490.

    Article  PubMed  CAS  Google Scholar 

  49. Han, Q.B., Song, J.Z., Qiao, C.F., Wong, L., and Xu, H.X., J. Chromatogr. A, 2006, vol. 1127, p. 298.

    Article  PubMed  CAS  Google Scholar 

  50. Ye, H., Ignatova, S., Luo, H., Li, Y., Peng, A., Chen, L., and Sutherland, I., J. Chromatogr. A, 2008, vol. 1213, p. 145.

    Article  PubMed  CAS  Google Scholar 

  51. Xie, J., Deng, J., Tan, F., and Su, J., J. Chromatogr. B: Anal. Technol. Biomed. Life Sci., 2010, vol. 878, p. 2665.

    Article  CAS  Google Scholar 

  52. Tong, S., Guan, Y.-X., Yan, J., Zheng, B., and Zhao, L., J. Chromatogr. A, 2011, vol. 1218, p. 5434.

    Article  PubMed  CAS  Google Scholar 

  53. Yang, J., Ye, H., Lai, H., Li, S., He, S., Zhong, S., Chen, L., and Peng, A., J. Sep. Sci., 2012, vol. 35, p. 256.

    Article  PubMed  CAS  Google Scholar 

  54. Meng, J., Yang, Z., Liang, J., Zhou, H., and Wu, S., J. Chromatogr. A, 2014, vol. 1327, p. 27.

    Article  PubMed  CAS  Google Scholar 

  55. Friesen, J.B., McAlpine, J.B., Chen, S.-N., and Pauli, G.F., J. Nat. Prod., 2015, vol. 78, p. 1765.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  56. Chen, Y., Yan, X., Lu, F., Jiang, X., Friesen, J.B., Pauli, G.F., Chen, S.-N., and Li, D.-P., J. Chromatogr. A, 2019, vol. 1599, p. 180.

    Article  PubMed  CAS  Google Scholar 

  57. Kostanyan, A.E., J. Chromatogr. A, 2015, vol. 1406, p. 156.

    Article  PubMed  CAS  Google Scholar 

  58. Kostanyan, A.E., J. Chromatogr. A, 2015, vol. 1423, p. 71.

    Article  PubMed  CAS  Google Scholar 

  59. Kostanyan, A.E. and Erastov, A., J. Chromatogr. A, 2016, vol. 1462, p. 55.

    Article  PubMed  CAS  Google Scholar 

  60. Lee, Y.W., J. Chromatogr. A, 1991, vol. 538, p. 37.

    Article  CAS  Google Scholar 

  61. Delannay, E., Toribio, A., Boudesocque, L., Nuzillard, J.-M., Zeches-Hanrot, M., Dardennes, E., Le Dour, G., Sapi, J., and Renault, J.-H., J. Chromatogr. A, 2006, vol. 1127, p. 45.

    Article  PubMed  CAS  Google Scholar 

  62. Hewitsona, P., Ignatova, S., Ye, H., Chen, L., and Sutherland, I., J. Chromatogr. A, 2009, vol. 1216, p. 4187.

    Article  CAS  Google Scholar 

  63. Rubioa, N., Ignatova, S., Minguillona, C., and Sutherland, I., J. Chromatogr. A, 2009, vol. 1216, p. 8505.

    Article  CAS  Google Scholar 

  64. Yang, Y., Aisa, H.A., and Ito, Y., J. Chromatogr. A, 2009, vol. 1216, p. 6310.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  65. Aihua, P., Haoyu, Y., Jie, S., Shichao, H., Shijie, Z., Shucai, L., and Lijuan, C., J. Chromatogr. A, 2010, vol. 1217, p. 5935.

    Article  CAS  Google Scholar 

  66. Ignatova, S., Hewitson, P., Mathews, B., and Sutherland, I., J. Chromatogr. A, 2011, vol. 1218, p. 6102.

    Article  PubMed  CAS  Google Scholar 

  67. Hewitson, P., Ignatova, S., and Sutherland, I., J. Chromatogr. A, 2011, vol. 1218, p. 6053.

    Article  CAS  Google Scholar 

  68. Mekaoui, N. and Berthod, A., J. Chromatogr. A, 2011, vol. 1218, p. 6061.

    Article  PubMed  CAS  Google Scholar 

  69. Goll, J., Frey, A., and Minceva, M., J. Chromatogr. A, 2013, vol. 1284, p. 59.

    Article  PubMed  CAS  Google Scholar 

  70. Huang, X.-Y., Ignatova, S., Hewitson, P., and Di, D.-L., TrAC, Trends Anal. Chem., 2016, vol. 77, p. 214.

    Article  CAS  Google Scholar 

  71. Goll, J., Morley, R., and Minceva, M., J. Chromatogr. A, 2017, vol. 1469, p. 68.

    Article  CAS  Google Scholar 

  72. Morley, R. and Minceva, M., J. Chromatogr. A, 2019, vol. 1594, p. 140.

    Article  PubMed  CAS  Google Scholar 

  73. Hewitson, P., Sutherland, I., Kostanyan, A.E., Voshkin, A.A., and Ignatova, S., J. Chromatogr. A, 2013, vol. 1303, p. 18.

    Article  PubMed  CAS  Google Scholar 

  74. Kostanyan, A.E., Ignatova, S., Sutherland, I., Hewitson, P., Zakhodjaeva, Y.A., and Erastov, A.A., J. Chromatogr. A, 2013, vol. 1314, p. 94.

    Article  PubMed  CAS  Google Scholar 

  75. Kostanyan, A.E., Khol’kin, A.I., Erastov, A.A., and Belova, V.V., RF Patent Application 2014144416, 2015.

  76. Kostanyan, A.E., Erastov, A.A., and Shishilov, O.N., J. Chromatogr. A, 2014, vol. 1347, p. 87.

    Article  PubMed  CAS  Google Scholar 

  77. Kostanyan, A.E. and Belova, V.V., J. Chromatogr. A, 2019, vol. 1588, p. 174.

    Article  PubMed  CAS  Google Scholar 

  78. Kostanyan, A.E. and Galieva, Z.N., J. Chromatogr. A, 2019, vol. 1603, p. 240.

    Article  PubMed  CAS  Google Scholar 

  79. Berthod, A., Friesen, J.B., Inui, T., and Pauli, G.F., Anal. Chem., 2007, vol. 79, p. 3371.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  80. Kostanyan, A.E., J. Chromatogr. A, 2011, vol. 1218, p. 6412.

    Article  PubMed  CAS  Google Scholar 

  81. Ma, T., Dong, H., Lu, H., Zhao, H., Guo, L., and Wang, X., J. Chromatogr. A, 2018, vol. 1578, p. 61.

    Article  PubMed  CAS  Google Scholar 

  82. das Neves Costa, F., Neves Vieira, M., Garrard, I., Hewitson, P., Jerz, G., Guimarães Leitao, G.G., and Ignatova, S., J. Chromatogr. A, 2016, vol. 1466, p. 76.

    Article  CAS  Google Scholar 

  83. Müller, M., Wasmer, K., and Vetter, W., J. Chromatogr. A, 2018, vol. 1556, p. 88.

    Article  PubMed  CAS  Google Scholar 

  84. Peng, A., Hewitson, P., Sutherland, I., Chen, L., and Ignatova, S., J. Chromatogr. A, 2018, vol. 1580, p. 120.

    Article  PubMed  CAS  Google Scholar 

  85. Delannay, E., Toribio, A., Boudesocque, L., Nuzillard, J.M., Zeches-Hanrot, M., and Dardennes, E., Le Dour, G., Sapi, J., Renault, J.-H., J. Chromatogr. A, 2006, vol. 1127, p. 45.

    Article  PubMed  CAS  Google Scholar 

  86. Kostanyan, A. and Martynova, M., J. Chromatogr. A, 2020, vol. 1614.

  87. Kostanyan, A.E., J. Chromatogr. A, 2014, vol. 1373, p. 81.

    Article  PubMed  CAS  Google Scholar 

  88. Kostanyan, A.E. and Erastov, A.A., J. Chromatogr. A, vol. 1406, p. 118.

  89. Kostanyan, A.E. and Shishilov, O.N., J. Chromatogr. A, 2018, vol. 1552 P, p. 92.

  90. Kostanyan, A.E., J. Chromatogr. A, 2017, vol. 1506, p. 82.

    Article  PubMed  CAS  Google Scholar 

  91. Kostanyan, A., Martynova, M., Erastov, A., and Belova, V., J. Chromatogr. A, 2018, vol. 1560, p. 26.

    Article  PubMed  CAS  Google Scholar 

  92. Kostanyan, A.E., Voshkin, A.A., Khol’kin, A.I., and Belova, V.V., RF Patent 2403949, 2010.

  93. Kostanyan, A.E., Voshkin, A.A., and Kodin, N.V., Theor. Found. Chem. Eng., 2011, vol. 45, no. 5, p. 779.

    Article  CAS  Google Scholar 

  94. Kostanyan, A.E. and Voshkin, A.A., J. Chromatogr. A, 2009, vol. 1216, p. 7761.

    Article  PubMed  CAS  Google Scholar 

  95. Kostanyan, A.E., Voshkin, A.A., and Kodin, N.V., J. Chromatogr. A, 2011, vol. 1218, p. 6135.

    Article  PubMed  CAS  Google Scholar 

  96. Kostanyan, A.E., Russ. J. Inorg. Chem., 2017, vol. 63, p. 287.

    Article  Google Scholar 

  97. Kostanyan, A.E. and Erastov, A.A., J. Chromatogr. A, 2018, vol. 1572, p. 212.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 119991, Moscow, Russia

    A. E. Kostanyan

Authors
  1. A. E. Kostanyan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. E. Kostanyan.

Additional information

Translated by O. Zhukova

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kostanyan, A.E. Increasing Efficiency of the Separation of Substance Mixtures by Methods of Liquid–Liquid Chromatography. J Anal Chem 75, 1384–1398 (2020). https://doi.org/10.1134/S1061934820110088

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1061934820110088

Keywords:

Search

Navigation