Abstract
The reaction of methyl esters of 2-substituted 5-pyrimidinecarboxylic acids with hydrazine hydrate at 0–5°C results in the nucleophilic substitution of readily eliminating groups (Cl, CH3O, CH3S) at the position 2 of the pyrimidine ring, and, on the boiling with the 80% aqueous solution of hydrazine hydrate, the reaction is accompanied by the formation of hydrazides. The dimethylamino group at thepposition 2 of the pyrimidine ring is not substituted by hydrazine.
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Vilnius University, Vilnius 2006, Lithuania Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1528–1530, November, 1999.
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Tumkevicius, S., Yakubkene, V. & Vainilavicius, P. Reaction of esters of 2-substituted 5-pyrimidinecarboxylic acids with hydrazine hydrate. Chem Heterocycl Compd 35, 1334–1336 (1999). https://doi.org/10.1007/BF02252004
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DOI: https://doi.org/10.1007/BF02252004