Abstract
The drift patterns of the mandible, presphenoid, and femur were compared in calves fed graded levels (2 deficient, 2 control) of vitamin A for 16 weeks. In addition, gross measurements of endochondral growth were recorded. The results indicated that drift of deficient bones was altered because subperiosteal resorption failed and was often replaced by growth. On those periosteal surfaces where resorption was not required for normal modeling, little effect was found due to treatment. In light of the evidence that osteoclasts disappear from the periosteal surfaces during deficiency, it is suggested that vitamin A affects the ability of the periosteal progenitor cell to differentiate as an osteoclast.
Résumé
Une comparaison du remainiement osseux de la mandibule, du présphénoide et du fémur de veaux, recevant des quantités variables de vitamin A (2 doses carentielles et 2 doses de contrôle) pendant une durée de 16 semaines, a été réalisée. La croissance enchondrale a également été étudiée.
Les résultats indiquent une altération du remaniement des os carencés, liée à une déficience de la résorption sous-périostée, cette dernière étant souvent remplacée par de l'apposition. Le traitement eut peu ou pas d'effet au niveau des surfaces périostées, où le remaniement normal ne nécessite pas de résorption. Etant donné que les osteéoclastes ne sont plus visibles au niveau des surfaces périostées au cours de l'état de carence, il semble que la vitamine A soit susceptible d'agir sur la differenciation de la cellule ostéogénique périostée en ostéoclaste.
Zusammenfassung
Der Knochenumbau wurde in Unterkiefer, Präsphenoid und Femur von 4 Gruppen von Kälbern verglichen. Diese erhielten während einer Zeitspanne von 16 Wochen verschiedene Vitamin A-Mengen (2 Vitamin A-Mangel- und 2 Kontrollgruppen). Ferner wurde das endochondrale Wachstum grob gemessen. Die Resultate ergaben eine Veränderung des Umbaus von defizienten Knochen wegen der mangelhaften subperiostalen Resorption, die oft durch Wachstum ersetzt wurde. Jene periostalen Oberflächen, wo die Resorption für einen normalen Umbau nicht erforderlicht ist, wurden durch den Vitamin A-Mangel nur wenig beeinflußt. Die Tatsache, daß die Osteoklasten bei Vitamin A-Mangel von den periostalen Oberflächen verschwinden, läßt vermuten, daß Vitamin A die Fähigkeit der periostalen Stammzellen, sich zu Osteoklasten zu differenzieren, beeinflußt.
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These studies were supported by U.S. National Institutes of Health Grants GM-1199 and NB-02108.
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Hayes, K.C., Cousins, R.J. Vitamin A deficiency and bone growth. Calc. Tis Res. 6, 120–132 (1970). https://doi.org/10.1007/BF02196191
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DOI: https://doi.org/10.1007/BF02196191