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Fehlende Wasserstoff-Übertragung von Östradiol auf Androstendion im Diäthylnitrosamin-induzierten Hepatom der Ratte

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Summary

In liver-tissue of female rats estradiol-17 α-T is oxydized by NAD or NADP, yielding the tritiumlabelled coenzymes NAD-T or NADP-T which can transfer the tritium to androstendione. So tritium-labelled androstandiol is obtained. Of the added activity 10–30% is oxydized to water. In diethylnitrosamine-induced hepatomas estradiol-17 α-T is oxydized to tritium-water in a comparatively small amount and no transport of the tritium to reduction-products of androstendions occurs. Testing the in-vivo-oxydation of estradiol in normal female rats and in females with hepatoma with the aid of the ‘Stoffwechsel-labil’ labelling (measuring the specific activity of tritium in body-water after injecting estradiol-17 α-T) a lower oxydation-rate was also found in rats with hepatoma than in normal rats.

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Authors and Affiliations

  1. Physiologisch-Chemisches Institut der Freien Universität, 1 Berlin-Dahlem, Deutschland

    M. Wenzel & K. Pollow

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  1. M. Wenzel
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  2. K. Pollow
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Wenzel, M., Pollow, K. Fehlende Wasserstoff-Übertragung von Östradiol auf Androstendion im Diäthylnitrosamin-induzierten Hepatom der Ratte. Experientia 24, 553–555 (1968). https://doi.org/10.1007/BF02153768

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  • DOI: https://doi.org/10.1007/BF02153768

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