Abstract
One hundred and eight male Sprague-Dawley rats weighing 160–225 g were examined with vitreous fluorophotometry (VF). Fifty-five rats were made diabetic with streptozocin (43 with 65 mg/kg and 12 with 90 mg/kg); 53 nondiabetic rats served as controls. Fluorescein (7 mg/kg) was injected IV and VF was performed 60 min later. The diabetic rats had an abnormal blood-retinal barrier (BRB) after 4–7 days duration. The difference between the diabetic and non-diabetic rats was persistent up to 35 days (P < 0.02−0.001). The diabetic rats treated with 90 mg/kg streptozotocin had a more severe diabetes and a higher fluorescein concentration in the vitreous body than those treated with 65 mg/kg (P < 0.05). The BRB function was normalized in 18 rats treated for 6–7 days with 5–6 IU long-acting insulin (P < 0.02). The results imply that streptozocin-diabetic rats have an abnormal BRB and that this abnormality seems to be related to the diabetic state and to be reversible after insulin treatment.
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Kernell, A., Dahlkvist, H., Arnqvist, H. et al. Influence of metabolic control on the blood-retinal barrier in streptozocin diabetic rats. Graefe's Arch Clin Exp Ophthalmol 222, 179–181 (1985). https://doi.org/10.1007/BF02133669
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DOI: https://doi.org/10.1007/BF02133669