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Experimental infection of cynomolgus monkeys with a human retrovirus, adult T-cell leukemia virus

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Abstract

The experimental infection of six cynomolgus monkeys with adult T-cell leukemia virus (ATLV) was attempted. Three animals were inoculated with living MT-2 cells and three with cell-free ATLV. All animals developed an antibody response to virus-specific glycopolypeptides and viral core polypeptides. ATLV-specific antigens appeared in peripheral lymphocytes from all six animals. Virus expression persisted in all animals. Up to 40 weeks after inoculation no animal developed any symptom of leukemia.

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Authors and Affiliations

  1. Institute for Virus Research, Kyoto University, 606, Kyoto, Japan

    N. Yamamoto, M. Okada & Y. Hinuma

  2. Institute of Medical Science, University of Tokyo, 108, Tokyo, Japan

    M. Hayami & A. Komuro

  3. German Primate Centre, D-3400, Göttingen, Germany

    J. Schneider & G. Hunsmann

Authors
  1. N. Yamamoto
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  2. M. Hayami
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  3. A. Komuro
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  4. J. Schneider
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  5. G. Hunsmann
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  6. M. Okada
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  7. Y. Hinuma
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Yamamoto, N., Hayami, M., Komuro, A. et al. Experimental infection of cynomolgus monkeys with a human retrovirus, adult T-cell leukemia virus. Med Microbiol Immunol 173, 57–64 (1984). https://doi.org/10.1007/BF02123570

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  • DOI: https://doi.org/10.1007/BF02123570

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